罗利环素

• 常用名: 罗利环素
• 英文名: Rolitetracycline
• CAS号: 751-97-3
• 分子量: 527.57
• 密度: 1.542g/cm3
• 沸点: 824.37ºC at 760 mmHg
• 分子式: C₂₇H₃₃N₃O₈
• 熔点: 163.5°C
• 闪点: 452.363ºC
• 符号: GHS07
• 信号词: Warning

罗利环素用途

Rolitetracycline,四环素衍生物,是一种广谱抗生素。Rolitetracycline 作为蛋白质合成抑制剂、抗原生动物药物和前药发挥作用。

罗利环素名称

• 中文名: 罗利环素
• 英文名: rolitetracycline

罗利环素生物活性

• 描述: Rolitetracycline,四环素衍生物,是一种广谱抗生素。Rolitetracycline 作为蛋白质合成抑制剂、抗原生动物药物和前药发挥作用。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. SMITH L, ROLITETRACYCLINE, AN ANTIBIOTIC FOR PARENTERAL USE. (SYNTETRIN, VELACYCLINE). JAMA. 1964 Jan 11;187:141.

  [2]. Rolitetracycline

  [3]. Blackwood R K, et al. Structure–Activity Relationships in the Tetracycline Series. Advances in applied microbiology, 1970, 13:237-266.

罗利环素物理化学性质

• 密度: 1.542g/cm3
• 沸点: 824.37ºC at 760 mmHg
• 熔点: 163.5°C
• 分子式: C₂₇H₃₃N₃O₈
• 分子量: 527.57
• 闪点: 452.363ºC
• 精确质量: 527.22700
• PSA: 170.87000
• LogP: 0.79860
• InChIKey: IKQRPFTXKQQLJF-IAHYZSEUSA-N
• SMILES: CN(C)C1C(=O)C(C(=O)NCN2CCCC2)=C(O)C2(O)C(=O)C3=C(O)c4c(O)cccc4C(C)(O)C3CC12
• 折射率: 1.713
• 储存条件: 2-8℃

罗利环素毒性和生态

罗利环素安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22-36/37/38
• 安全声明 (欧洲): 26-36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 1
• RTECS号: QI9150000

罗利环素靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291801

实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291798

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measu... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291791

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：Identifying Sarm1 Tir Hydrolase inhibitors through NAD-Glo assay 来源：24386 靶标：N/A External Id：Sarm1 Tir NADase inhibitors screen

实验名称：Binding affinity towards human DRD2 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL5291781

实验名称：Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resol... 来源：ChEMBL 靶标：D(1A) dopamine receptor External Id：CHEMBL5291777

实验名称：Antagonist activity at human CNR1 in an in vitro cell-based assay measured by fluores... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL5291772

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罗利环素英文别名

• synotodecin
• rolitetracyclin
• sq15,659
• Syntodecin
• ROLITETRACYCLINE
• prm-tc
• Transcycline
• superciclin
• syntetrin
• N-pyrrolidinomethyl-tetracycline
• bristacin
• syntetrex
• reverin
• N-Pyrrolidinomethyl-tetracyclin
• velacicline