碘普罗胺

更新时间:2024-01-02 18:18:18

碘普罗胺结构式
碘普罗胺结构式
品牌特惠专场
常用名 碘普罗胺 英文名 iopromide
CAS号 73334-07-3 分子量 791.112
密度 2.2±0.1 g/cm3 沸点 840.9±65.0 °C at 760 mmHg
分子式 C18H24I3N3O8 熔点 broad (160ºC transition)
MSDS 美版 闪点 462.4±34.3 °C
符号 GHS09
GHS09
信号词 Warning

 碘普罗胺用途


Iopromide是用于血管内给药的水溶的低渗透非离子型X射线造影剂。

 碘普罗胺名称

中文名 碘普罗胺
英文名 iopromide
中文别名 N,N'-双(2,3-二羟丙基)-2,4,6-三碘-5-[(2-甲氧基乙酰基)氨基]-N'-甲基苯基-1,3-甲酰胺
英文别名 更多

 碘普罗胺生物活性

描述 Iopromide是用于血管内给药的水溶的低渗透非离子型X射线造影剂。
相关类别
体内研究 尾静脉注射碘普罗胺可诱导造影剂中引起的肾病[1]。在随机对照试验中,iobitridol的全球图像质量和诊断质量与其他低渗造影剂(碘海醇,碘普罗胺,碘帕醇,碘美普尔和异恶唑)或等渗造影剂碘克沙醇在成人或儿童中的差异无统计学差异射线照相成像。大型上市后监测研究证实,iobitridol可产生良好或极好的混浊,是绝大多数患者的有效造影剂。碘比特醇通常具有良好的耐受性,并且具有与其他低渗和等渗对比剂相似的耐受性特征。因此,iobitridol是一种有效的血管内药物,用于诊断成像中的对比度增强[2]。
动物实验 小鼠:雄性C57 / BL6J小鼠随机分为7组:对照组,糖尿病组(D),CIN,糖尿病+ CIN(DC),糖尿病+灯盏花素(DB),CIN +灯盏花素(CIN + B)和糖尿病mellitus + CIN +灯盏花素(DCB)。在建立糖尿病模型后,禁止小鼠饮水一晚,然后在1分钟内通过尾静脉给药以10mL / kg碘普罗胺的剂量注射小鼠。然后用或不用灯盏花素(10mg / kg / d)对小鼠进行胃内治疗4周。除灯盏花素处理组(DB,DCB和CIN + B)之外的其他小鼠组在胃内给予相同体积的磷酸盐缓冲溶液4周。然后通过腹膜内注射水合氯醛处死小鼠[1]。
参考文献

[1]. Jiang W, et al. Breviscapine attenuatted contrast medium-induced nephropathy via PKC/Akt/MAPK signalling in diabetic mice. Am J Transl Res. 2016 Feb 15;8(2):329-41.

[2]. McCormack PL, et al. Iobitridol: a review of its use as a contrast medium in diagnostic imaging. Clin Drug Investig. 2013 Feb;33(2):155-66.

 碘普罗胺物理化学性质

密度 2.2±0.1 g/cm3
沸点 840.9±65.0 °C at 760 mmHg
熔点 broad (160ºC transition)
分子式 C18H24I3N3O8
分子量 791.112
闪点 462.4±34.3 °C
精确质量 790.869690
PSA 168.66000
LogP -2.95
外观性状 灰白色至白色粉末
蒸汽压 0.0±3.3 mmHg at 25°C
折射率 1.710
储存条件 Hygroscopic, -20?C Freezer, Under Inert Atmosphere
稳定性 Hygroscopic

 碘普罗胺毒性和生态

 碘普罗胺安全信息

符号 GHS09
GHS09
信号词 Warning
危害声明 H410
警示性声明 P273-P501
危害码 (欧洲) N
风险声明 (欧洲) 50/53
安全声明 (欧洲) 60-61
危险品运输编码 NONH for all modes of transport
RTECS号 CZ2230000
海关编码 2924299090

 碘普罗胺合成线路

~85%

碘普罗胺结构式

碘普罗胺

73334-07-3

文献:LG LIFE SCIENCES LTD. Patent: WO2009/134030 A1, 2009 ; Location in patent: Page/Page column 11 - 12 ;

 碘普罗胺海关

海关编码 2924299090
中文概述 2924299090. 其他环酰胺(包括环氨基甲酸酯)(包括其衍生物以及他们的盐). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 包装
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 碘普罗胺文献114

更多文献
Adverse skin reactions to iodinated x-ray contrast agents in healthy rats.

Invest. Radiol. 49(12) , 779-87, (2014)

The aim of this preclinical study on healthy Sprague-Dawley rats was to determine whether differences exist in the induction of adverse skin reactions after the intravenous administration of a monomer...

Analysis of the roles of glucose transporter 1 and hexokinase 2 in the metabolism of glucose by extrahepatic bile duct cancer cells.

Clin. Nucl. Med. 40(3) , e178-82, (2015)

Extrahepatic bile duct (EHD) cancer varies in uptake of FDG. The aim of the present study was to determine the role of glucose transporter (GLUT) 1 and hexokinase (HK) 2 in the glucose metabolism of E...

Ventilation/perfusion mismatch during lung aeration at birth.

J. Appl. Physiol. 117(5) , 535-43, (2014)

At birth, the transition to newborn life is triggered by lung aeration, which stimulates a large increase in pulmonary blood flow (PBF). Current theories predict that the increase in PBF is spatially ...

 碘普罗胺英文别名

iopromide
N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(méthoxyacétyl)amino]-N-méthylbenzène-1,3-dicarboxamide
N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methylisophthalamide
Ultravist
1,3-Benzenedicarboxamide, N,N-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N-methyl-
iopromida
5-Methoxyacetylamino-2,4,6-triiodoisophthalic Acid [(2,3-Dihydroxy-N-methylpropyl)-(2,3-dihydroxypropyl)]diamide
N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiod-5-[(methoxyacetyl)amino]-N-methylbenzol-1,3-dicarboxamid
iopromidum
N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-N-methyl-5-{[(methyloxy)acetyl]amino}benzene-1,3-dicarboxamide
1,3-benzenedicarboxamide, N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methyl-
EINECS 277-385-9
Ultravist 300
N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methyl-1,3-benzenedicarboxamide
N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methylbenzene-1,3-dicarboxamide
Ultravist 370
UNII:712BAC33MZ
SHL 414C
1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-3-N-methylbenzene-1,3-dicarboxamide
MFCD00867924
品牌现货直购
推荐供应商:









查看所有供应商和价格请点击:

碘普罗胺生产厂家

碘普罗胺价格