ABT-670结构式
|
常用名 | ABT-670 | 英文名 | ABT-670 |
|---|---|---|---|---|
| CAS号 | 630119-43-6 | 分子量 | 325.40500 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C19H23N3O2 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | N/A |
ABT-670用途ABT-670是一种具有选择性，可口服的dopamine D4受体抑制剂。 |
| 中文名 | ABT-670 |
|---|---|
| 英文名 | 3-methyl-N-[[4-(1-oxidopyridin-1-ium-2-yl)piperidin-1-yl]methyl]benzamide |
| 英文别名 | 更多 |
| 描述 | ABT-670是一种具有选择性,可口服的dopamine D4受体抑制剂。 |
|---|---|
| 相关类别 | |
| 靶点 |
EC50: 89 nM (Human D4), 160 nM (Ferret D4), 93 nM (Rat D4)[1] |
| 体外研究 | ABT-670是一种选择性D4激动剂,对人D4,雪貂D4和大鼠D4的EC50分别为89 nM,160 nM和93 nM [1]。 |
| 体内研究 | ABT-670(0.1μmol/ kg)可强烈诱导雄性大鼠勃起的高发(75％)。 ABT-670在大鼠,狗和猴中表现出优异的口服生物利用度(分别为68％,85％和91％),具有相当的疗效,安全性和耐受性[1]。 |
| 参考文献 |
| 分子式 | C19H23N3O2 |
|---|---|
| 分子量 | 325.40500 |
| 精确质量 | 325.17900 |
| PSA | 61.29000 |
| LogP | 3.50310 |
| 储存条件 | 2-8℃ |
|
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ABT-670 630119-43-6 |
| 文献：Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q. Patent: US2003/229094 A1, 2003 ; Location in patent: Page 98 ; US 20030229094 A1 |
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ABT-670 630119-43-6 |
| 文献：Patel, Meena V.; Kolasa, Teodozyj; Mortell, Kathleen; Matulenko, Mark A.; Hakeem, Ahmed A.; Rohde, Jeffrey J.; Nelson, Sherry L.; Cowart, Marlon D.; Nakane, Masaki; Miller, Loan N.; Uchic, Marie E.; Terranova, Marc A.; El-Kouhen, Odile F.; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Chang, Renjie; Martino, Brenda R.; Wetter, Jill M.; Marsh, Kennan C.; Martin, Ruth; Darbyshire, John F.; Gintant, Gary; Hsieh, Gin C.; Moreland, Robert B.; Sullivan, James P.; Brioni, Jorge D.; Stewart, Andrew O. Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7450 - 7465 |
|
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ABT-670 630119-43-6 |
| 文献：Patel, Meena V.; Kolasa, Teodozyj; Mortell, Kathleen; Matulenko, Mark A.; Hakeem, Ahmed A.; Rohde, Jeffrey J.; Nelson, Sherry L.; Cowart, Marlon D.; Nakane, Masaki; Miller, Loan N.; Uchic, Marie E.; Terranova, Marc A.; El-Kouhen, Odile F.; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Chang, Renjie; Martino, Brenda R.; Wetter, Jill M.; Marsh, Kennan C.; Martin, Ruth; Darbyshire, John F.; Gintant, Gary; Hsieh, Gin C.; Moreland, Robert B.; Sullivan, James P.; Brioni, Jorge D.; Stewart, Andrew O. Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7450 - 7465 |
|
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ABT-670 630119-43-6 |
| 文献：Patel, Meena V.; Kolasa, Teodozyj; Mortell, Kathleen; Matulenko, Mark A.; Hakeem, Ahmed A.; Rohde, Jeffrey J.; Nelson, Sherry L.; Cowart, Marlon D.; Nakane, Masaki; Miller, Loan N.; Uchic, Marie E.; Terranova, Marc A.; El-Kouhen, Odile F.; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Chang, Renjie; Martino, Brenda R.; Wetter, Jill M.; Marsh, Kennan C.; Martin, Ruth; Darbyshire, John F.; Gintant, Gary; Hsieh, Gin C.; Moreland, Robert B.; Sullivan, James P.; Brioni, Jorge D.; Stewart, Andrew O. Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7450 - 7465 |
|
~%
ABT-670 630119-43-6 |
| 文献：Patel, Meena V.; Kolasa, Teodozyj; Mortell, Kathleen; Matulenko, Mark A.; Hakeem, Ahmed A.; Rohde, Jeffrey J.; Nelson, Sherry L.; Cowart, Marlon D.; Nakane, Masaki; Miller, Loan N.; Uchic, Marie E.; Terranova, Marc A.; El-Kouhen, Odile F.; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Chang, Renjie; Martino, Brenda R.; Wetter, Jill M.; Marsh, Kennan C.; Martin, Ruth; Darbyshire, John F.; Gintant, Gary; Hsieh, Gin C.; Moreland, Robert B.; Sullivan, James P.; Brioni, Jorge D.; Stewart, Andrew O. Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7450 - 7465 |
|
~%
ABT-670 630119-43-6 |
| 文献：Patel, Meena V.; Kolasa, Teodozyj; Mortell, Kathleen; Matulenko, Mark A.; Hakeem, Ahmed A.; Rohde, Jeffrey J.; Nelson, Sherry L.; Cowart, Marlon D.; Nakane, Masaki; Miller, Loan N.; Uchic, Marie E.; Terranova, Marc A.; El-Kouhen, Odile F.; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Chang, Renjie; Martino, Brenda R.; Wetter, Jill M.; Marsh, Kennan C.; Martin, Ruth; Darbyshire, John F.; Gintant, Gary; Hsieh, Gin C.; Moreland, Robert B.; Sullivan, James P.; Brioni, Jorge D.; Stewart, Andrew O. Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7450 - 7465 |
| 2-(1-{[(3-methylbenzoyl)amino]methyl}-4-piperidinyl)pyridinium N-oxide |
| UNII-4L6071XH2J |
| Benzamide,3-methyl-N-[[4-(1-oxido-2-pyridinyl)-1-piperidinyl]methyl] |
| ABT-670 |
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