盐酸CP-640186

• 常用名: 盐酸CP-640186
• 英文名: CP-640186 hydrochloride
• CAS号: 591778-70-0
• 分子量: 522.078
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₃₆ClN₃O₃
• 熔点: N/A
• 闪点: N/A

盐酸CP-640186用途

CP-640186盐酸盐是乙酰辅酶A羧化酶（ACCase）抑制剂，对鼠肝ACCase1和骨骼肌ACCase2的IC50s分别为53 nM和61 nM，比CP-610431有着更好的代谢稳定性。

盐酸CP-640186名称

• 中文名: 盐酸CP-640186
• 英文名: 9-Anthryl[(3R)-3-(4-morpholinylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone hydrochloride (1:1)

盐酸CP-640186生物活性

• 描述: CP-640186 hydrochloride是一种有效且可透过细胞的乙酰辅酶A羧化酶 (ACC)抑制剂,抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的 IC50为53 nM和61 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 乙酰辅酶A羧化酶
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278(39):37099-111.

  [2]. Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.

盐酸CP-640186物理化学性质

• 分子式: C₃₀H₃₆ClN₃O₃
• 分子量: 522.078
• 精确质量: 521.244507
• 储存条件: 2-8℃

盐酸CP-640186英文别名

• 9-Anthryl[(3R)-3-(4-morpholinylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone hydrochloride (1:1)
• Methanone, 9-anthracenyl[(3R)-3-(4-morpholinylcarbonyl)[1,4'-bipiperidin]-1'-yl]-, hydrochloride (1:1)
• CP-640186 hydrochloride
• CP-640186 (hydrochloride)