鹅去氧胆酸-13C同位素

更新时间:2024-01-19 16:05:54

鹅去氧胆酸-13C同位素结构式
鹅去氧胆酸-13C同位素结构式
品牌特惠专场
常用名 鹅去氧胆酸-13C同位素 英文名 Chenodeoxycholic acid-13C
CAS号 52918-92-0 分子量 393.56500
密度 N/A 沸点 N/A
分子式 C24H40O4 熔点 N/A
MSDS N/A 闪点 N/A

 鹅去氧胆酸-13C同位素用途


鹅去氧胆酸-13C(CDCA-13C)是13C标记的鹅去氧胆酸。鹅去氧胆酸是一种疏水性初级胆汁酸,可激活参与胆固醇代谢的核受体(FXR)。

 鹅去氧胆酸-13C同位素名称

中文名 鹅去氧胆酸-13C同位素
英文名 chenodeoxycholic acid-24-13c
英文别名 更多

 鹅去氧胆酸-13C同位素生物活性

描述 鹅去氧胆酸-13C(CDCA-13C)是13C标记的鹅去氧胆酸。鹅去氧胆酸是一种疏水性初级胆汁酸,可激活参与胆固醇代谢的核受体(FXR)。
相关类别
体外研究 氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
参考文献

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Stauffer AT, et al. Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor. J Biol Chem. 2002 Jul 19;277(29):26286-92

[3]. Casaburi I, et al. Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation. Cell Cycle. 2012 Jul 15;11(14):2699-710

[4]. Kawabe Y, et al. The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells. Biochem Biophys Res Commun. 1995 Mar 8;208(1):405-11.

[5]. Ao M, et al. Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells. Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C447-56

[6]. Noh K, et al. Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1/2-mediated phosphorylation of CCAAT/enhancer binding protein β. Drug Metab

 鹅去氧胆酸-13C同位素物理化学性质

分子式 C24H40O4
分子量 393.56500
精确质量 393.29600
PSA 77.76000
LogP 4.47790

 鹅去氧胆酸-13C同位素英文别名

<24-13C>-Chenodeoxycholsaeure
<2.2.2.2>Cyclophan
<24><1,2,3,4>cyclophane