异欧前胡素结构式
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常用名 | 异欧前胡素 | 英文名 | Isoimperatorin |
|---|---|---|---|---|
| CAS号 | 482-45-1 | 分子量 | 270.280 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 448.3±45.0 °C at 760 mmHg | |
| 分子式 | C16H14O4 | 熔点 | 109ºC | |
| MSDS | 中文版 美版 | 闪点 | 224.9±28.7 °C |
异欧前胡素用途Isoimperatorin 是Angelica dahurica 根的甲醇提取物,有效抑制乙酰胆碱酯酶 (AChE),IC50 为 74.6 μM。 |
| 中文名 | 异欧前胡素 |
|---|---|
| 英文名 | isoimperatorin |
| 中文别名 | 4-(3-甲基丁-2-烯氧基)呋喃并[3,2-g]苯并吡喃-7-酮 | 4-(3-甲基丁-2-烯氧基)呋喃并[3,2-g]苯并吡喃-7-酮 | 白芷甲素 |
| 英文别名 | 更多 |
| 描述 | Isoimperatorin 是Angelica dahurica 根的甲醇提取物,有效抑制乙酰胆碱酯酶 (AChE),IC50 为 74.6 μM。 |
|---|---|
| 相关类别 | |
| 靶点 |
IC50: 74.6 μM (AChE)[1] |
| 体外研究 | 在针对中草药新农药的筛选计划中,发现羌活根茎的乙醇提取物对两种线虫,松材线虫和南方根结线虫具有强烈的杀线虫活性。基于生物活性引导的分级分离,从乙醇提取物中分离出四种成分,并鉴定为Columbianetin,Falcarindiol,Falcarinol和Isoimperatorin。异欧前胡素对B. xylophilus的LC50值为21.83μg/ mL。当使用15分钟的紫外线光照处理时,镰刀菌醇,镰刀菌素和异欧前胡素对南方根结线虫的毒性几乎是黑暗处理的5倍,而哥伦比亚的毒性仅为毒性的2倍。已经证明异欧前胡素具有对几种昆虫的杀虫活性,如卷心菜蚜虫(Brevicoryne brassicae)[2]。在白芷(AD)提取物的活性部分中鉴定出异欧前胡素[3]。异欧前胡素通常用作内标(IS)[4]。 |
| 参考文献 |
| 密度 | 1.2±0.1 g/cm3 |
|---|---|
| 沸点 | 448.3±45.0 °C at 760 mmHg |
| 熔点 | 109ºC |
| 分子式 | C16H14O4 |
| 分子量 | 270.280 |
| 闪点 | 224.9±28.7 °C |
| 精确质量 | 270.089203 |
| PSA | 52.58000 |
| LogP | 3.88 |
| 外观性状 | 白色粉末 |
| 蒸汽压 | 0.0±1.1 mmHg at 25°C |
| 折射率 | 1.606 |
| 储存条件 | -20°C Freezer |
| 危险品运输编码 | NONH for all modes of transport |
|---|---|
| RTECS号 | LV1513000 |
|
~75%
异欧前胡素 482-45-1 |
| 文献：Row; Brown; Stachulski; Lennard Organic and Biomolecular Chemistry, 2006 , vol. 4, # 8 p. 1604 - 1610 |
|
~%
异欧前胡素 482-45-1 |
| 文献：Row; Brown; Stachulski; Lennard Organic and Biomolecular Chemistry, 2006 , vol. 4, # 8 p. 1604 - 1610 |
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In vitro activity of isoimperatorin, alone and in combination, against Mycobacterium tuberculosis.
Lett. Appl. Microbiol. 58(4) , 344-9, (2014) Previous studies have shown that isoimperatorin (IO), a furanocoumarin isolated from several medicinal plants, has antimycobacterial activity against Mycobacterium tuberculosis strain H37Rv (ATCC 2729... |
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Study on pharmacokinetics and tissue distribution of pteryxin in mice by ultra-pressure liquid chromatography with tandem mass spectrometry.
Biomed. Chromatogr. 26(7) , 802-7, (2012) Pteryxin is a coumarin compound naturally occurring in the roots of Radix Peucedani, a commonly used as traditional Chinese medicine for the treatment of certain respiratory diseases and hypertension.... |
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Ethyl acetate extract from Angelica Dahuricae Radix inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E2 and tumor necrosis factor-alphavia mitogen-activated protein kinases and nuclear factor-kappaB in macrophages.
Pharmacol. Res. 55(4) , 263-70, (2007) Angelica dahurica (Umbelliferae) has been used to treat headache of common cold, supraorbital neuralgia, painful swelling on the body, nasal stuffiness, leukorrhea and arthralgia due to wind-dampness ... |
| 7H-Furo[3,2-g][1]benzopyran-7-one, 4-[(3-methyl-2-buten-1-yl)oxy]- |
| IisoiMperatorin |
| buten-1-yl)oxy] |
| 7H-Furo[3,2-g][1]benzopyran-7-one, 4-[(3-methyl-2-butenyl)oxy]- |
| Iso Imperatorin |
| Isoimperatoin |
| MFCD00272155 |
| 4-[(3-Methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one |
| 7H-Furo[3,2-g][1]benzopyran-7-one, 4-((3-methyl-2-butenyl)oxy)- |
| Isoimperatorin |
| 4-PRENYLOXYPSORALEN |
| Isomperatorin |
| Auraptin |
| isoimperatonin |
| 4-[(3-Methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one |
| 7H-Furo(3,2-g)(1)benzopyran-7-one, 4-((3-methyl-2-butenyl)oxy)- |
| Cnidin |
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