醋酸环丙孕酮

更新时间:2019-03-09 18:32:41

醋酸环丙孕酮结构式
醋酸环丙孕酮结构式
常用名 醋酸环丙孕酮 英文名 Cyproterone acetate
CAS号 427-51-0 分子量 402.91
密度 1.3±0.1 g/cm3 沸点 525.9±50.0 °C at 760 mmHg
分子式 C23H27ClO4 熔点 200-201ºC
MSDS 中文版 美版 闪点 177.6±29.1 °C
符号 GHS07 GHS08
GHS07, GHS08
信号词 Warning

 醋酸环丙孕酮用途


Cyproterone醋酸盐是高活性雄激素受体(AR)拮抗剂,IC50为7.1 nM,还是弱的孕酮受体激动剂。

 醋酸环丙孕酮作用


抗雄性激素,用于治疗男性良性前列腺肥大症,并可用作男性避孕药

 醋酸环丙孕酮名称

中文名 环丙氯地孕酮
英文名 cyproterone acetate
中文别名 醋酸环丙孕酮 | 醋酸环丙孕酮 | 环丙孕酮醋酸盐 | 6-氯-1α,2α-亚甲基-4,6-孕甾二烯-17α-羟基-3,20-二酮-17-醋酸酯 | 奈非西坦
英文别名 更多

 醋酸环丙孕酮物理化学性质

密度 1.3±0.1 g/cm3
沸点 525.9±50.0 °C at 760 mmHg
熔点 200-201ºC
分子式 C23H27ClO4
分子量 402.91
闪点 177.6±29.1 °C
PSA 60.44000
LogP 3.28
外观性状 气味
蒸汽压 0.0±1.4 mmHg at 25°C
折射率 1.582
储存条件 2-8°C
水溶解性 Practically insoluble in water, very soluble in methylene chloride, freely soluble in acetone, soluble in methanol, sparingly soluble in anhydrous ethanol.
计算化学

1.疏水参数计算参考值(XlogP):3.6

2.氢键供体数量:0

3.氢键受体数量:4

4.可旋转化学键数量:3

5.互变异构体数量:10

6.拓扑分子极性表面积:60.4

7.重原子数量:29

8.表面电荷:0

9.复杂度:903

10.同位素原子数量:0

11.确定原子立构中心数量:8

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

 醋酸环丙孕酮毒性和生态

 醋酸环丙孕酮安全信息

符号 GHS07 GHS08
GHS07, GHS08
信号词 Warning
危害声明 H312 + H332-H351
警示性声明 P261-P280
个人防护装备 Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲) Xn:Harmful
风险声明 (欧洲) R20/21/22;R40
安全声明 (欧洲) S26-S36
危险品运输编码 NONH for all modes of transport
WGK德国 3
RTECS号 GZ2230000
海关编码 2937290090

 醋酸环丙孕酮海关

海关编码 2937290090

 醋酸环丙孕酮文献69

更多文献
Estrogen and androgen regulate actin-remodeling and endocytosis-related genes during rat spermiation.

Mol. Cell. Endocrinol. 404 , 91-101, (2015)

Spermiation, the sperm release process, is imperative to male fertility and reproduction. Morphologically, it is characterized by removal of atypical adherens junctions called ectoplasmic specializati...

Effects of the anti-androgen cyproterone acetate (CPA) on oocyte meiotic maturation in rainbow trout (Oncorhynchus mykiss).

Aquat. Toxicol. 164 , 34-42, (2015)

In the present study, we aimed at characterizing the effect of cyproterone acetate (CPA), an anti-androgenic compound, on oocyte meiotic maturation in a freshwater teleost fish species, the rainbow tr...

Preservation of volumetric bone density and geometry in trans women during cross-sex hormonal therapy: a prospective observational study.

Osteoporos. Int. 26(1) , 35-47, (2015)

Although trans women before the start of hormonal therapy have a less bone and muscle mass compared with control men, their bone mass and geometry are preserved during the first 2 years of hormonal th...

 醋酸环丙孕酮英文别名

Cyprostat
(3aS,3bR,7aR,8aS,8bS,8cS,10aS)-1-Acetyl-5-chloro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate
Cyprosterone acetate
6-Chloro-1b,2b-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-Acetate
Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1α,2α-methylene-, acetate
Cyproterone 17-O-acetate
Cyproteron acetate
SH 714
(1R,3aS,3bR,7aR,8aS,8bS,8cS,10aS)-1-Acetyl-5-chloro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate
Cyproterone acetate
androcur
Cyproterone 17α-acetate
(1b,2b)-17-(Acetyloxy)-6-chloro-1,2-dihydro-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
cPA
Cyproteron-R acetate
CpA (VAN)
Cyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one, 1-acetyl-1-(acetyloxy)-5-chloro-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydro-8b,10a-dimethyl-, (1R,3aS,3bR,7aR,8aS,8bS,8cS,10aS)-
Cyproterone (acetate)
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参考价格:$86/10mM*1mLinDMSO

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