醋酸环丙孕酮

更新时间：2024-01-02 18:07:29

醋酸环丙孕酮结构式	常用名	醋酸环丙孕酮	英文名	Cyproterone acetate
	CAS号	427-51-0	分子量	402.91
	密度	1.3±0.1 g/cm3	沸点	525.9±50.0 °C at 760 mmHg
	分子式	C₂₃H₂₇ClO₄	熔点	200-201ºC
	MSDS	中文版美版	闪点	177.6±29.1 °C
	符号	GHS07, GHS08	信号词	Warning

醋酸环丙孕酮用途 Cyproterone醋酸盐是高活性雄激素受体(AR)拮抗剂,IC50为7.1 nM,还是弱的孕酮受体激动剂。
醋酸环丙孕酮作用抗雄性激素，用于治疗男性良性前列腺肥大症，并可用作男性避孕药

中文名	环丙氯地孕酮
英文名	cyproterone acetate
中文别名	醋酸环丙孕酮 \| 醋酸环丙孕酮 \| 环丙孕酮醋酸盐 \| 6-氯-1α,2α-亚甲基-4,6-孕甾二烯-17α-羟基-3,20-二酮-17-醋酸酯 \| 奈非西坦
英文别名	更多

描述	Cyproterone醋酸盐是高活性雄激素受体(AR)拮抗剂,IC50为7.1 nM,还是弱的孕酮受体激动剂。
相关类别	信号通路 >> 其他 >> 雄激素受体研究领域 >> 内分泌
参考文献	[1]. Sonneveld, E., et al., Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays. Toxicol Sci, 2005. 83(1): p. 136-48. [2]. Attardi, B.J., S. Koduri, and S.A. Hild, Relative progestational and androgenic activity of four progestins used for male hormonal contraception assessed in vitro in relation to their ability to suppress LH secretion in the castrate male rat. Mol Cell End [3]. Arafa, N.M., Efficacy of echinacea on the action of cyproterone acetate in male rats. Pak J Biol Sci, 2010. 13(20): p. 966-76.

描述

Cyproterone醋酸盐是高活性雄激素受体(AR)拮抗剂,IC50为7.1 nM,还是弱的孕酮受体激动剂。

相关类别

信号通路 >> 其他 >> 雄激素受体

研究领域 >> 内分泌

参考文献

[1]. Sonneveld, E., et al., Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays. Toxicol Sci, 2005. 83(1): p. 136-48.

[2]. Attardi, B.J., S. Koduri, and S.A. Hild, Relative progestational and androgenic activity of four progestins used for male hormonal contraception assessed in vitro in relation to their ability to suppress LH secretion in the castrate male rat. Mol Cell End

[3]. Arafa, N.M., Efficacy of echinacea on the action of cyproterone acetate in male rats. Pak J Biol Sci, 2010. 13(20): p. 966-76.

密度	1.3±0.1 g/cm3
沸点	525.9±50.0 °C at 760 mmHg
熔点	200-201ºC
分子式	C₂₃H₂₇ClO₄
分子量	402.91
闪点	177.6±29.1 °C
PSA	60.44000
LogP	3.28
外观性状	气味
蒸汽压	0.0±1.4 mmHg at 25°C
折射率	1.582
储存条件	2-8°C
水溶解性	Practically insoluble in water, very soluble in methylene chloride, freely soluble in acetone, soluble in methanol, sparingly soluble in anhydrous ethanol.
计算化学	1.疏水参数计算参考值（XlogP）:3.6 2.氢键供体数量:0 3.氢键受体数量:4 4.可旋转化学键数量:3 5.互变异构体数量:10 6.拓扑分子极性表面积:60.4 7.重原子数量:29 8.表面电荷:0 9.复杂度:903 10.同位素原子数量:0 11.确定原子立构中心数量:8 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1

醋酸环丙孕酮毒性英文版

符号	GHS07, GHS08
信号词	Warning
危害声明	H312 + H332-H351
警示性声明	P261-P280
个人防护装备	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲)	Xn:Harmful
风险声明 (欧洲)	R20/21/22;R40
安全声明 (欧洲)	S26-S36
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	GZ2230000
海关编码	2937290090

海关编码	2937290090

Estrogen and androgen regulate actin-remodeling and endocytosis-related genes during rat spermiation.

Mol. Cell. Endocrinol. 404 , 91-101, (2015)

Spermiation, the sperm release process, is imperative to male fertility and reproduction. Morphologically, it is characterized by removal of atypical adherens junctions called ectoplasmic specializati...

Effects of the anti-androgen cyproterone acetate (CPA) on oocyte meiotic maturation in rainbow trout (Oncorhynchus mykiss).

Aquat. Toxicol. 164 , 34-42, (2015)

In the present study, we aimed at characterizing the effect of cyproterone acetate (CPA), an anti-androgenic compound, on oocyte meiotic maturation in a freshwater teleost fish species, the rainbow tr...

Preservation of volumetric bone density and geometry in trans women during cross-sex hormonal therapy: a prospective observational study.

Osteoporos. Int. 26(1) , 35-47, (2015)

Although trans women before the start of hormonal therapy have a less bone and muscle mass compared with control men, their bone mass and geometry are preserved during the first 2 years of hormonal th...

Cyprostat

(3aS,3bR,7aR,8aS,8bS,8cS,10aS)-1-Acetyl-5-chloro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate

Cyprosterone acetate

6-Chloro-1b,2b-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-Acetate

Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1α,2α-methylene-, acetate

Cyproterone 17-O-acetate

Cyproteron acetate

SH 714

(1R,3aS,3bR,7aR,8aS,8bS,8cS,10aS)-1-Acetyl-5-chloro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate

Cyproterone acetate

androcur

Cyproterone 17α-acetate

(1b,2b)-17-(Acetyloxy)-6-chloro-1,2-dihydro-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione

cPA

Cyproteron-R acetate

CpA (VAN)

Cyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one, 1-acetyl-1-(acetyloxy)-5-chloro-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydro-8b,10a-dimethyl-, (1R,3aS,3bR,7aR,8aS,8bS,8cS,10aS)-

Cyproterone (acetate)