孕二烯二酮结构式
|
常用名 | 孕二烯二酮 | 英文名 | (E)-Guggulsterone |
|---|---|---|---|---|
| CAS号 | 39025-24-6 | 分子量 | 312.446 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 463.3±45.0 °C at 760 mmHg | |
| 分子式 | C21H28O2 | 熔点 | 170-171.5° | |
| MSDS | 中文版 美版 | 闪点 | 172.3±25.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
孕二烯二酮用途(-)-(E)-古古尔甾酮是Z-古尔甾酮的代谢产物。Guggulsterone是guggulipid的一种活性成分,guggulipid是一种阿育吠陀药物,来源于Commiphora mukul。Guggulsterone具有降血脂活性[1]。 |
| 中文名 | 孕二烯二酮 |
|---|---|
| 英文名 | (E)-Guggulsterone |
| 中文别名 | 反式-固甾酮 | (17E)-孕甾-4,17(20)-二烯-3,16-二酮 |
| 英文别名 | 更多 |
| 密度 | 1.1±0.1 g/cm3 |
|---|---|
| 沸点 | 463.3±45.0 °C at 760 mmHg |
| 熔点 | 170-171.5° |
| 分子式 | C21H28O2 |
| 分子量 | 312.446 |
| 闪点 | 172.3±25.7 °C |
| 精确质量 | 312.208923 |
| PSA | 34.14000 |
| LogP | 3.65 |
| 蒸汽压 | 0.0±1.1 mmHg at 25°C |
| 折射率 | 1.557 |
| 储存条件 | 室温 |
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Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone.
Biochim. Biophys. Acta 1844(9) , 1684-93, (2014) Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative... |
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Guggulsterone attenuates cerulein-induced acute pancreatitis via inhibition of ERK and JNK activation.
Int. Immunopharmacol. 26 , 194-202, (2015) Guggulsterone (GS), a plant steroid and a compound found at high levels in Commiphora myrrha, exhibits anti-inflammatory, anti-cancer, and cholesterol-lowering effects. However, the potential of GS to... |
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CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.
Mol. Pharmacol. 87(5) , 878-89, (2015) Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that enhance the detoxification and elimination of xenobiotics and endobiotics by modulating the expression ... |
| Z-guggulsterone |
| UNII:9B259YE66O |
| E-guggulsterone |
| Pregna-4,17-diene-3,16-dione, (17E)- |
| trans-Guggulsterone |
| Guggulsterone |
| (17E)-Pregna-4,17-diene-3,16-dione |
| Pregna-4,17(20)-diene-3,16-dione, (17E)- |
| (17E)-Pregna-4,17(20)-diene-3,16-dione |
| GUGGULSTERONE E |
| GS,TRANS |
| GUGGULESTERONE E |
| GUGGULSTERONE, (E)- |
| Z-Guggulsteron |
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