N-[4-[(1R)-1-甲基-2-[[异丙基磺酰基]氨基]乙基]苯基]-3,5-二氟苯基甲酰胺

• 常用名: N-[4-[(1R)-1-甲基-2-[[异丙基磺酰基]氨基]乙基]苯基]-3,5-二氟苯基甲酰胺
• 英文名: LY450108
• CAS号: 376594-67-1
• 分子量: 396.451
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₉H₂₂F₂N₂O₃S
• 熔点: N/A
• 闪点: N/A

用途

LY450108是AMPA受体增强剂。

名称

• 中文名: N-[4-[(1R)-1-甲基-2-[[异丙基磺酰基]氨基]乙基]苯基]-3,5-二氟苯基甲酰胺
• 英文名: 3,5-difluoro-N-[4-[(2R)-1-(propan-2-ylsulfonylamino)propan-2-yl]phenyl]benzamide

生物活性

• 描述: LY450108是AMPA受体增强剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Simon E Ward1, Benjamin D Bax, Mark Harries. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology. 2010,160(2):181-190.

  [2]. O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20.

  [3]. Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32.

  [4]. Douglas A. Schober, Martin B. Gill, Hong Yu, et al. Transmembrane AMPA Receptor Regulatory Proteins and Cornichon-2 Allosterically Regulate AMPA Receptor Antagonists and Potentiators. The Journal of Biological Chemistry, 286, 13134-13142.

物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₁₉H₂₂F₂N₂O₃S
• 分子量: 396.451
• 精确质量: 396.131927
• PSA: 83.65000
• LogP: 3.41
• 折射率: 1.568
• 储存条件: 2-8℃

英文别名

• (R)-3,5-difluoro-N-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide
• QCR-13
• CS-1090
• Benzamide, 3,5-difluoro-N-[4-[(1R)-1-methyl-2-[[(1-methylethyl)sulfonyl]amino]ethyl]phenyl]-
• 3,5-Difluoro-N-(4-{(2R)-1-[(isopropylsulfonyl)amino]-2-propanyl}phenyl)benzamide
• LY450108