鲁比前列酮

• 常用名: 鲁比前列酮
• 英文名: Lubiprostone
• CAS号: 333963-40-9
• 分子量: 390.462
• 密度: 1.2±0.1 g/cm3
• 沸点: 532.3±50.0 °C at 760 mmHg
• 分子式: C₂₀H₃₂F₂O₅
• 熔点: N/A
• 闪点: 275.7±30.1 °C

鲁比前列酮用途

Lubiprostone, also known as RU-0211, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. It was initially approved by the U.S. Food and Drug Administration (FDA) in 2006. Lubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM).

鲁比前列酮名称

• 中文名: 鲁比前列素
• 英文名: (2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-heptanoic acid
• 中文别名: (2R,4AR,5R,7AR)-2-(1,1-二氟戊基)-2-羟基-6-氧代-3,4,4A,5,7,7A-六氢环戊并[B]吡喃-5-庚酸 | 鲁比前列酮 | 卢比前列酮

鲁比前列酮物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 532.3±50.0 °C at 760 mmHg
• 分子式: C₂₀H₃₂F₂O₅
• 分子量: 390.462
• 闪点: 275.7±30.1 °C
• 精确质量: 390.221771
• PSA: 83.83000
• LogP: 2.85
• 外观性状: 固体
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.486
• 储存条件: -20°C， 干燥

鲁比前列酮安全信息

• 危害码 (欧洲): Xn

鲁比前列酮英文别名

• (2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-h
• 7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl]heptanoic acid
• Prostan-1-oic acid, 11,15-epoxy-16,16-difluoro-15-hydroxy-9-oxo-, (11α,15R)-
• Spi 0211
• Lubiprostone
• Prostan-1-oic acid,11,15-epoxy-16,16-difluoro-15-hydroxy-9-oxo-,(11alpha,15R)
• (11α,15R)-16,16-Difluoro-15-hydroxy-9-oxo-11,15-epoxyprostan-1-oic acid
• 7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yI]heptanoic acid
• [3H]-Lubiprostone
• Unii-7662kg2R6k
• (-)-7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl]heptanoic acid