桑尼非拉姆

更新时间：2024-01-05 21:42:19

桑尼非拉姆结构式	常用名	桑尼非拉姆	英文名	DM 235
	CAS号	314728-85-3	分子量	246.305
	密度	1.2±0.1 g/cm3	沸点	442.0±38.0 °C at 760 mmHg
	分子式	C₁₄H₁₈N₂O₂	熔点	N/A
	MSDS	中文版美版	闪点	205.0±19.1 °C

桑尼非拉姆用途

Sunifiram (DM-235)是ampakine样化合物,具有较piracetam更好的益智活性。

中文名	1-(4-苯甲酰基哌嗪-1-基)-1-丙酮
英文名	1-(4-benzoylpiperazin-1-yl)propan-1-one
英文别名	更多

描述	Sunifiram (DM-235)是ampakine样化合物,具有较piracetam更好的益智活性。
相关类别	信号通路 >> 跨膜转运 >> iGluR 信号通路 >> 神经信号通路 >> iGluR 研究领域 >> 神经疾病
参考文献	[1]. Galeotti N, et al. AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):538-45. [2]. Moriguchi S, et al. Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor. Hippocampus. 2013 Jun 3. [3]. Moriguchi S, et al. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. Behav Brain Res. 2013 Apr 1;242:150-7.

描述

Sunifiram (DM-235)是ampakine样化合物,具有较piracetam更好的益智活性。

相关类别

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

参考文献

[1]. Galeotti N, et al. AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):538-45.

[2]. Moriguchi S, et al. Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor. Hippocampus. 2013 Jun 3.

[3]. Moriguchi S, et al. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. Behav Brain Res. 2013 Apr 1;242:150-7.

密度	1.2±0.1 g/cm3
沸点	442.0±38.0 °C at 760 mmHg
分子式	C₁₄H₁₈N₂O₂
分子量	246.305
闪点	205.0±19.1 °C
精确质量	246.136826
PSA	40.62000
LogP	0.26
蒸汽压	0.0±1.1 mmHg at 25°C
折射率	1.561
储存条件	2-8℃

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity.

J. Med. Chem. 43 , 4499, (2000)

Several 4-substituted 1-acylpiperazines, obtained by molecular simplification of 4-substituted 1,4-diazabicyclo[4.3.0]nonan-9-ones, have been synthesized and tested in vivo on the mouse passive avoida...

1-(4-Benzoyl-1-piperazinyl)-1-propanone

1-(4-Benzoylpiperazin-1-yl)propan-1-one

Lopac-D-5689

DM 235

DM-235

1-Propanone, 1-(4-benzoyl-1-piperazinyl)-

Sunifiram