尼博霉素

• 常用名: 尼博霉素
• 英文名: NSC 613948
• CAS号: 30408-30-1
• 分子量: 298.29300
• 密度: 1.54g/cm3
• 沸点: 538.7ºC at 760 mmHg
• 分子式: C₁₆H₁₄N₂O₄
• 熔点: N/A
• 闪点: 279.6ºC

尼博霉素用途

Nybomycin是一种抗生素,具有抗噬菌体和抗菌特性。Nybomycin与DNA结合,并诱导分枝杆菌发生独特的形态变化,导致细菌细胞死亡[1][2]。

尼博霉素名称

• 中文名: 尼博霉素
• 英文名: 8-(Hydroxymethyl)-6,11-dimethyl-4H-[1,3]oxazolo[5,4,3-ij]pyrido[3 ,2-g]quinoline-4,10(11H)-dione

尼博霉素生物活性

• 描述: Nybomycin是一种抗生素,具有抗噬菌体和抗菌特性。Nybomycin与DNA结合,并诱导分枝杆菌发生独特的形态变化,导致细菌细胞死亡[1][2]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Strelitz F, et, al. NYBOMYCIN, A NEW ANTIBIOTIC WITH ANTIPHAGE AND ANTIBACTERIAL PROPERTIES. Proc Natl Acad Sci U S A. 1955 Sep 15;41(9):620-4.

  [2]. Arai M, et, al. Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp. Bioorg Med Chem. 2015 Jul 1;23(13):3534-41.

尼博霉素物理化学性质

• 密度: 1.54g/cm3
• 沸点: 538.7ºC at 760 mmHg
• 分子式: C₁₆H₁₄N₂O₄
• 分子量: 298.29300
• 闪点: 279.6ºC
• 精确质量: 298.09500
• PSA: 73.46000
• LogP: 1.00400
• 蒸汽压: 1.95E-12mmHg at 25°C
• 折射率: 1.737

尼博霉素英文别名

• 8-(hydroxymethyl)-3,7-dimethyl-3,7-dihydro-1h-purine-2,6-dione
• 8-Hydroxymethyl-theobromin
• 8-Hydroxymethyl-3,7-dimethyl-3,7-dihydro-purin-2,6-dion
• 8-Hydroxymethyl-6,11-dimethyl-11H-oxazolo[5,4,3-ij]pyrido[3,2-g]chinolin-4,10-dion
• 8-hydroxymethyl-3,7-dimethyl-3,7-dihydro-purine-2,6-dione
• 8-Hydroxymethyltheobromine
• 8-hydroxymethyl-6,11-dimethyl-11H-oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10-dione