Abstract: steps, respectively, are described. Syntheses of the antibiotics nybomycin (1) and deoxynybomycin (2) from o-anisidine, in twelve and eight he antibiotic nybomycin was isolated several years T ago in two laboratories from streptomycete culture~;~~~ it was found to be quite active against Gram-positive and some Gram-negative bacteria, but its very limited solubility restricts its in vivo activity. The molecular structure of nybomycin has ...
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