Nybomycin. VII. Preparative routes to nybomycin and deoxynybomycin

RM Forbis, KL Rinehart

文献索引：Forbis,R.M.; Rinehart,K.L. Journal of the American Chemical Society, 1973 , vol. 95, p. 5003 - 5013

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被引用次数: 40

摘要

Abstract: steps, respectively, are described. Syntheses of the antibiotics nybomycin (1) and deoxynybomycin (2) from o-anisidine, in twelve and eight he antibiotic nybomycin was isolated several years T ago in two laboratories from streptomycete culture~;~~~ it was found to be quite active against Gram-positive and some Gram-negative bacteria, but its very limited solubility restricts its in vivo activity. The molecular structure of nybomycin has ...