罗伐他汀

更新时间：2024-01-03 00:08:13

罗伐他汀结构式	常用名	罗伐他汀	英文名	Rosuvastatin
	CAS号	287714-41-4	分子量	481.54
	密度	1.368 g/cm3	沸点	745.6ºC at 760 mmHg
	分子式	C₂₂H₂₈FN₃O₆S	熔点	N/A
	MSDS	N/A	闪点	404.7ºC

罗伐他汀用途

Rosuvastatin是竞争性HMG-CoA还原酶抑制剂,IC50为11 nM。

中文名	罗伐他汀
英文名	rosuvastatin
中文别名	7-[4-(4-氟苯基)-6-异丙基-2-(甲基-甲磺酰-氨基)-嘧啶-5-基]-3,5-二羟基庚-6-烯酸 \| 氘代罗苏伐他汀钠盐-d3 \| 瑞舒伐他汀酸
英文别名	更多

描述	Rosuvastatin是竞争性HMG-CoA还原酶抑制剂,IC50为11 nM。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR) 研究领域 >> 代谢疾病
参考文献	[1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44. [2]. Schneck, D.W., et al., The effect of gemfibrozil on the pharmacokinetics of rosuvastatin. Clin Pharmacol Ther, 2004. 75(5): p. 455-63. [3]. Kim, Y.S., et al., Rosuvastatin suppresses the inflammatory responses through inhibition of c-Jun N-terminal kinase and Nuclear Factor-kappaB in endothelial cells. J Cardiovasc Pharmacol, 2007. 49(6): p. 376-83. [4]. Carswell, C.I., G.L. Plosker, and B. Jarvis, Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7. [5]. Stalker, T.J., A.M. Lefer, and R. Scalia, A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. Br J Pharmacol, 2001. 133(3): p. 406-12.

描述

Rosuvastatin是竞争性HMG-CoA还原酶抑制剂,IC50为11 nM。

相关类别

信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)

研究领域 >> 代谢疾病

参考文献

[1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44.

[2]. Schneck, D.W., et al., The effect of gemfibrozil on the pharmacokinetics of rosuvastatin. Clin Pharmacol Ther, 2004. 75(5): p. 455-63.

[3]. Kim, Y.S., et al., Rosuvastatin suppresses the inflammatory responses through inhibition of c-Jun N-terminal kinase and Nuclear Factor-kappaB in endothelial cells. J Cardiovasc Pharmacol, 2007. 49(6): p. 376-83.

[4]. Carswell, C.I., G.L. Plosker, and B. Jarvis, Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7.

[5]. Stalker, T.J., A.M. Lefer, and R. Scalia, A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. Br J Pharmacol, 2001. 133(3): p. 406-12.

密度	1.368 g/cm3
沸点	745.6ºC at 760 mmHg
分子式	C₂₂H₂₈FN₃O₆S
分子量	481.54
闪点	404.7ºC
PSA	152.13000
LogP	2.14780
蒸汽压	2.38E-23mmHg at 25°C
折射率	1.597
储存条件	2-8°C

罗伐他汀上游产品 9
CAS号355805-96-8 Rosuvastatin me... CAS号147118-39-6 瑞舒伐他汀中间体H-2 CAS号1007871-85-3 tert-butyl 2-[6... CAS号852820-97-4 (+)-7-[4-(4-flu...
CAS号289042-12-2 6-[(1E)-2-[4-(4... CAS号147118-40-9 瑞舒伐他汀中间体H-3 CAS号355806-00-7 瑞舒伐他汀叔丁酯 CAS号851443-04-4 瑞舒伐他汀乙酯
CAS号147118-37-4 4-(4-氟苯基)-6-异丙基...
罗伐他汀下游产品 1
CAS号503610-43-3 瑞舒伐他汀-5S-内酯

Reference source: Negwer

volume-3 compound no

ROSUVASTATIN-D3 SODIUM SALT

7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid

6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl-d(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, sodium salt, (3R,5S,6E)- (1:1)

[3H]-Rosuvastatin

Rosuvastatin

Sodium (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[(H)methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoate

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-MethylMethanesulfonaMido)-6-(propan-2-yl)pyriMidin-5-yl]-3,5-dihydroxyhept-6-enoic acid

MFCD08460959