密旋霉素
密旋霉素结构式
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常用名 | 密旋霉素 | 英文名 | Pactamycin |
|---|---|---|---|---|
| CAS号 | 23668-11-3 | 分子量 | 558.62300 | |
| 密度 | 1.38g/cm3 | 沸点 | 784.2ºC at 760mmHg | |
| 分子式 | C28H38N4O8 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 428.1ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
密旋霉素用途Pactamycin (NSC 52947) is a potent protein synthesis inhibitor, inhibits protein synthesis at the translocation step on the 70S ribosome, has activity against Gram-positive and Gram-negative bacteria, and broad antitumor, antiviral, and antiplasmodial act |
| 中文名 | 密旋霉素 |
|---|---|
| 英文名 | Benzoic acid,2-hydroxy-6-methyl-,[(1S,2R,3R,4S,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methylester |
| 英文别名 | 更多 |
| 密度 | 1.38g/cm3 |
|---|---|
| 沸点 | 784.2ºC at 760mmHg |
| 分子式 | C28H38N4O8 |
| 分子量 | 558.62300 |
| 闪点 | 428.1ºC |
| 精确质量 | 558.26900 |
| PSA | 194.68000 |
| LogP | 1.91870 |
| 蒸汽压 | 6.66E-26mmHg at 25°C |
| 折射率 | 1.645 |
| 符号 |
GHS06 |
|---|---|
| 信号词 | Danger |
| 危害声明 | H300-H315-H319-H335 |
| 警示性声明 | P261-P264-P301 + P310-P305 + P351 + P338 |
| 危险品运输编码 | UN 2811 6.1 / PGII |
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Enantioselective synthesis of pactamycin, a complex antitumor antibiotic.
Science 340(6129) , 180-2, (2013) Medicinal application of many complex natural products is precluded by the impracticality of their chemical synthesis. Pactamycin, the most structurally intricate aminocyclopentitol antibiotic, displa... |
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Total synthesis of pactamycin and pactamycate: a detailed account.
J. Org. Chem. 77(21) , 9458-72, (2012) This article describes synthetic studies that culminated in the first total synthesis of pactamycin and pactamycate and, in parallel, the two known congeners, de-6-MSA-pactamycin and de-6-MSA-pactamyc... |
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Diastereocontrolled construction of pactamycin's complex ureido triol functional array.
Org. Lett. 14(11) , 2878-81, (2012) An advanced intermediate in a projected synthesis of pactamycin has been prepared. Early installation of the C1-dimethylurea functionality allows for its participation in a diastereoselective, chelati... |
| Pactamycin |
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- 上海源溪生物科技有限公司
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- 产品名：Pactamycin
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