AGN 194310

• 常用名: AGN 194310
• 英文名: AGN 194310
• CAS号: 229961-45-9
• 分子量: 424.554
• 密度: 1.3±0.1 g/cm3
• 沸点: 598.1±50.0 °C at 760 mmHg
• 分子式: C₂₈H₂₄O₂S
• 熔点: N/A
• 闪点: 315.5±30.1 °C

AGN 194310用途

AGN 194310(VTP-194310)是RAR激动剂，对RARα/β/γ的Kd分别为3/2/5 nM。

AGN 194310名称

• 中文名: AGN 194310
• 英文名: AGN 194310

AGN 194310生物活性

• 描述: AGN 194310(VTP-194310)是RAR激动剂,对RARα/β/γ的Kd分别为3/2/5 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> RAR/RXR
  研究领域 >> 癌症
• 参考文献:

  [1]. Johnson AT, et al. Synthesis and biological activity of high-affinity retinoic acid receptor antagonists. Bioorg Med Chem. 1999 Jul;7(7):1321-38.

  [2]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62.

  [3]. Austenaa LM, et al. Vitamin A status significantly alters nuclear factor-kappaB activity assessed by in vivo imaging. FASEB J. 2004 Aug;18(11):1255-7.

  [4]. Walkley CR, et al. Retinoic acid receptor antagonism in vivo expands the numbers of precursor cells during granulopoiesis. Leukemia. 2002 Sep;16(9):1763-72.

AGN 194310物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 598.1±50.0 °C at 760 mmHg
• 分子式: C₂₈H₂₄O₂S
• 分子量: 424.554
• 闪点: 315.5±30.1 °C
• 精确质量: 424.149689
• LogP: 9.56
• InChIKey: LHUPKWKWYWOMSK-UHFFFAOYSA-N
• SMILES: CCc1ccc(C2=CC(C)(C)Sc3ccc(C#Cc4ccc(C(=O)O)cc4)cc32)cc1
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.683
• 储存条件: 2-8℃

AGN 194310英文别名

• 4-{[4-(4-Ethylphenyl)-2,2-dimethyl-2H-thiochromen-6-yl]ethynyl}benzoic acid
• Benzoic acid, 4-[2-[4-(4-ethylphenyl)-2,2-dimethyl-2H-1-benzothiopyran-6-yl]ethynyl]-