garenoxacin mesylate

• 常用名: garenoxacin mesylate
• 英文名: garenoxacin mesylate
• CAS号: 223652-82-2
• 分子量: 522.52
• 密度: 1.421g/cm3
• 沸点: 581.5ºC at 760mmHg
• 分子式: C₂₄H₂₄F₂N₂O₇S
• 熔点: N/A
• 闪点: 305.5ºC

garenoxacin mesylate用途

甲磺酸加诺沙星(BMS 284756)是一种口服活性喹诺酮类抗生素,对多种革兰氏阳性和革兰氏阴性细菌、厌氧菌具有广谱活性。甲磺酸加诺沙星还抑制Gyrase和TOPO IV[1][2][3][4]。

garenoxacin mesylate名称

• 英文名: garenoxacin mesylate

garenoxacin mesylate生物活性

• 描述: 甲磺酸加诺沙星(BMS 284756)是一种口服活性喹诺酮类抗生素,对多种革兰氏阳性和革兰氏阴性细菌、厌氧菌具有广谱活性。甲磺酸加诺沙星还抑制Gyrase和TOPO IV[1][2][3][4]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点:

  1.25 μg/mL (Gyrase), 1.5-2.5 μg/mL (TOPO IV)[2]

• 参考文献:

  [1]. Waites KB, et al. In vitro susceptibilities to and bactericidal activities of garenoxacin (BMS-284756) and other antimicrobial agents against human mycoplasmas and ureaplasmas. Antimicrob Agents Chemother. 2003 Jan;47(1):161-5.

  [2]. Ince D, et al. Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone. Antimicrob Agents Chemother. 2002 Nov;46(11):3370-80.

  [3]. Zhao X, et al. Mutant prevention concentration of garenoxacin (BMS-284756) for ciprofloxacin-susceptible or -resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2003 Mar;47(3):1023-7.

  [4]. Azoulay-Dupuis E, et al. Activities of garenoxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model. Antimicrob Agents Chemother. 2004 Mar;48(3):765-73.

garenoxacin mesylate物理化学性质

• 密度: 1.421g/cm3
• 沸点: 581.5ºC at 760mmHg
• 分子式: C₂₄H₂₄F₂N₂O₇S
• 分子量: 522.52
• 闪点: 305.5ºC
• 精确质量: 522.12700
• PSA: 143.31000
• LogP: 5.38080
• InChIKey: UPHLDCUEQOTSAD-RFVHGSKJSA-N
• SMILES: CC1NCc2cc(-c3ccc4c(=O)c(C(=O)O)cn(C5CC5)c4c3OC(F)F)ccc21.CS(=O)(=O)O

garenoxacin mesylate英文别名

• Garenoxacin Mesilate