Griffipavixanthone

• 常用名: Griffipavixanthone
• 英文名: Griffipavixanthone
• CAS号: 219649-95-3
• 分子量: 652.60
• 密度: 1.6±0.1 g/cm3
• 沸点: 862.8±65.0 °C at 760 mmHg
• 分子式: C₃₆H₂₈O₁₂
• 熔点: N/A
• 闪点: 277.7±27.8 °C

Griffipavixanthone用途

Griffipavixanthone可以从藤中提取。Griffipavixanthone通过伴随ROS产生的线粒体凋亡途径诱导细胞凋亡。格里菲沙酮是一种抗癌剂。Griffipavixanthone是一种弱蔗糖酶抑制剂(IC50:4.58mM)[1][2][3]。

Griffipavixanthone名称

• 英文名: (8S,8aS,12aR)-1,3,6,7-Tetrahydroxy-9,9,11-trimethyl-8-(3,4,6,8-te trahydroxy-9-oxo-9H-xanthen-1-yl)-8a,9,10,12a-tetrahydroindeno[1, 2-a]xanthen-13(8H)-one

Griffipavixanthone生物活性

• 描述: Griffipavixanthone可以从藤中提取。Griffipavixanthone通过伴随ROS产生的线粒体凋亡途径诱导细胞凋亡。格里菲沙酮是一种抗癌剂。Griffipavixanthone是一种弱蔗糖酶抑制剂(IC50:4.58mM)[1][2][3]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Lien Do TM, et al. Schomburgkixanthone, a novel bixanthone from the twigs of Garcinia schomburgkiana. Nat Prod Res. 2021 Nov;35(21):3613-3618.

  [2]. Shi JM, et al. Griffipavixanthone from Garcinia oblongifolia champ induces cell apoptosis in human non-small-cell lung cancer H520 cells in vitro. Molecules. 2014 Jan 27;19(2):1422-31.

  [3]. Ma Y, et al. Griffipavixanthone induces apoptosis of human breast cancer MCF-7 cells in vitro. Breast Cancer. 2019 Mar;26(2):190-197.

Griffipavixanthone物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 862.8±65.0 °C at 760 mmHg
• 分子式: C₃₆H₂₈O₁₂
• 分子量: 652.60
• 闪点: 277.7±27.8 °C
• 精确质量: 652.158081
• PSA: 222.26000
• LogP: 4.32
• 外观性状: 棕色粉末
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.772
• 储存条件: 2-8℃，干燥，密闭

Griffipavixanthone安全信息

• 危害码 (欧洲): Xi

Griffipavixanthone英文别名

• (8S,8aS,12aR)-1,3,6,7-Tetrahydroxy-9,9,11-trimethyl-8-(3,4,6,8-tetrahydroxy-9-oxo-9H-xanthen-1-yl)-8a,9,10,12a-tetrahydroindeno[1,2-a]xanthen-13(8H)-one
• Indeno[1,2-a]xanthen-13(8H)-one, 8a,9,10,12a-tetrahydro-1,3,6,7-tetrahydroxy-9,9,11-trimethyl-8-(3,4,6,8-tetrahydroxy-9-oxo-9H-xanthen-1-yl)-, (8S,8aS,12aR)-