N-[(4'-溴[1,1'-联苯]-4-基)磺酰基]-L-缬氨酸

• 常用名: N-[(4'-溴[1,1'-联苯]-4-基)磺酰基]-L-缬氨酸
• 英文名: PD 166793
• CAS号: 199850-67-4
• 分子量: 412.29800
• 密度: 1.457g/cm3
• 沸点: 562.069ºC at 760 mmHg
• 分子式: C₁₇H₁₈BrNO₄S
• 熔点: 192-193℃
• 闪点: 293.729ºC

用途

PD-166793 is a cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 μM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 μM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.

名称

• 中文名: (S)-2-(4’-溴联苯-4-磺酰胺)-3-甲基丁酸
• 英文名: (2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid
• 中文别名: N-[(4'-溴[1,1'-联苯]-4-基)磺酰基]-L-缬氨酸

物理化学性质

• 密度: 1.457g/cm3
• 沸点: 562.069ºC at 760 mmHg
• 熔点: 192-193℃
• 分子式: C₁₇H₁₈BrNO₄S
• 分子量: 412.29800
• 闪点: 293.729ºC
• 精确质量: 411.01400
• PSA: 91.85000
• LogP: 4.97530
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.597
• 储存条件: Desiccate at +4°C