Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors

PM O'Brien, DF Ortwine, AG Pavlovsky…

文献索引：O'Brien, Patrick M.; Ortwine, Daniel F.; Pavlovsky, Alexander G.; Picard, Joseph A.; Sliskovic, Drago R.; Roth, Bruce D.; Dyer, Richard D.; Johnson, Linda L.; Man, Chiu Fai; Hallak, Hussein Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 156 - 166

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被引用次数: 106

摘要

A series of biphenylsulfonamide derivatives of (S)-2-(biphenyl-4-sulfonylamino)-3- methylbutyric acid (5) were prepared and evaluated for their ability to inhibit matrix metalloproteinases (MMPs). For this series of compounds, our objective was to systematically replace substituents appended to the biphenyl and α-position of 5 with structurally diverse functionalities to assess the effects these changes have on biological ...