CFM-2

• 常用名: CFM-2
• 英文名: CFM 2
• CAS号: 178616-26-7
• 分子量: 311.33500
• 密度: 1.32g/cm3
• 沸点: N/A
• 分子式: C₁₇H₁₇N₃O₃
• 熔点: N/A
• 闪点: N/A

CFM-2用途

CFM-2是AMPAR选择非竞争性抑制剂。

CFM-2名称

• 中文名: 1-(4-氨基苯基)-3,5-二氢-7,8-二甲氧基-4H-2,3-苯并二氮杂-4-酮
• 英文名: 1-(4-aminophenyl)-7,8-dimethoxy-3,5-dihydro-2,3-benzodiazepin-4-one

CFM-2生物活性

• 描述: CFM-2是AMPAR选择非竞争性抑制剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. De Sarro G, et al. Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. Eur J Pharmacol. 1999 Mar 5;368(2-3):149-59.

  [2]. Rizzo M, et al. Determination of new 2,3-benzodiazepines in rat plasma using high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Sci Appl. 1999 Aug 20;731(2):207-15.

  [3]. Stepulak A, et al. AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth. Cancer Biol Ther. 2007 Dec;6(12):1908-15.

  [4]. Park JS, et al. Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain. Mol Pain. 2008 Dec 30;4:67.

CFM-2物理化学性质

• 密度: 1.32g/cm3
• 分子式: C₁₇H₁₇N₃O₃
• 分子量: 311.33500
• 精确质量: 311.12700
• PSA: 85.94000
• LogP: 2.05630
• 折射率: 1.637
• 储存条件: 2-8℃

CFM-2英文别名

• Eeyarestatin I
• Tocris-1082
• CFM-2