爱维莫潘

• 常用名: 爱维莫潘
• 英文名: Alvimopan
• CAS号: 170098-38-1
• 分子量: 460.563
• 密度: 1.166g/cm3
• 沸点: 684.1ºC at 760mmHg
• 分子式: C₂₅H₃₆N₂O₆
• 熔点: 210-213ºC
• 闪点: 367.5ºC

爱维莫潘用途

Alvimopan(LY 246736; ADL 8-2698)二水合物是新型的口服外周阿片样受体（PAM-OR）拮抗剂，IC50为1.7 nM。

爱维莫潘名称

• 中文名: 爱维莫潘二水合物
• 英文名: 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid,dihydrate
• 中文别名: 爱维莫潘杂质

爱维莫潘生物活性

• 描述: Alvimopan(LY 246736; ADL 8-2698)二水合物是新型的口服外周阿片样受体(PAM-OR)拮抗剂,IC50为1.7 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体
  信号通路 >> 神经信号通路 >> 阿片受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. NCBI BioAssay: 325959

  [2]. Cassel JA, et al. [(3)H]Alvimopan binding to the micro opioid receptor: comparative binding kinetics of opioid antagonists. Eur J Pharmacol. 2005 Sep 27;520(1-3):29-36.

  [3]. Viscusi ER, et al. Alvimopan, a peripherally acting mu-opioid receptor antagonist, compared with placebo in postoperative ileus after major abdominal surgery: results of a randomized, double-blind, controlled study. Surg Endosc. 2006 Jan;20(1):64-70.

  [4]. Fukuda H, et al. The selective mu opioid receptor antagonist, alvimopan, improves delayed GI transit of postoperative ileus in rats. Brain Res. 2006 Aug 2;1102(1):63-70.

  [5]. Delaney CP, et al. Phase III trial of alvimopan, a novel, peripherally acting, mu opioid antagonist, for postoperative ileus after major abdominal surgery. Dis Colon Rectum. 2005 Jun;48(6):1114-25; discussion 1125-6; author reply 1127-9.

爱维莫潘物理化学性质

• 密度: 1.166g/cm3
• 沸点: 684.1ºC at 760mmHg
• 熔点: 210-213ºC
• 分子式: C₂₅H₃₆N₂O₆
• 分子量: 460.563
• 闪点: 367.5ºC
• 精确质量: 460.257324
• PSA: 108.33000
• LogP: 3.25160
• InChIKey: USPVLEIQIUNQGE-DBFLIVQGSA-N
• SMILES: CC1CN(CC(Cc2ccccc2)C(=O)NCC(=O)O)CCC1(C)c1cccc(O)c1.O.O
• 外观性状: 粉末
• 蒸汽压: 1.18E-19mmHg at 25°C
• 折射率: 1.572
• 储存条件: -20℃

爱维莫潘毒性和生态

爱维莫潘英文别名

• Alvimopan dihydrate
• Alvimopan
• N-{(2S)-2-Benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]propanoyl}glycine dihydrate
• Glycine, N-[(2S)-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]-1-oxo-2-(phenylmethyl)propyl]-, hydrate (1:2)
• Alvimopan (USAN)
• Adl 8-2698
• Alvimopan anhydrous
• UNII-677C126AET
• Alvimopan hydrate
• Entereg
• Alvimopan (dihydrate)