ONC-201 Dihydrochloride结构式
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常用名 | ONC-201 Dihydrochloride | 英文名 | ONC-201 Dihydrochloride |
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CAS号 | 1638178-82-1 | 分子量 | 459.411 | |
密度 | N/A | 沸点 | N/A | |
分子式 | C24H28Cl2N4O | 熔点 | N/A | |
MSDS | N/A | 闪点 | N/A |
ONC-201 Dihydrochloride用途ONC-201, also known as TIC10 and imipridone, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL. |
英文名 | ONC-201 DIHYDROCHLORIDE |
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英文别名 | 更多 |
分子式 | C24H28Cl2N4O |
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分子量 | 459.411 |
精确质量 | 458.164032 |
Imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)-, hydrochloride (1:2) |
7-Benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one dihydrochloride |
ONC-201 DIHYDROCHLORIDE |