1638178-82-1

• 常用中文名：ONC-201 Dihydrochloride
• 常用英文名：ONC-201 Dihydrochloride
• CAS号：1638178-82-1
• 分子式：C₂₄H₂₈Cl₂N₄O
• 分子量：459.411
• 发布时间：2021-01-07 17:53:11
• 更新时间：2024-01-12 13:46:23
• ONC-201, also known as TIC10 and imipridone, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL.

名称

• 英文名: ONC-201 DIHYDROCHLORIDE
• 英文别名: Imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)-, hydrochloride (1:2); 7-Benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one dihydrochloride; ONC-201 DIHYDROCHLORIDE

物化性质

• 分子式: C₂₄H₂₈Cl₂N₄O
• 分子量: 459.411
• 精确质量: 458.164032