替比培南酯

更新时间：2024-01-02 15:24:43

替比培南酯结构式	常用名	替比培南酯	英文名	Tebipenem Pivoxil
	CAS号	161715-24-8	分子量	497.628
	密度	1.5±0.1 g/cm3	沸点	661.9±65.0 °C at 760 mmHg
	分子式	C₂₂H₃₁N₃O₆S₂	熔点	140-142℃
	MSDS	N/A	闪点	354.1±34.3 °C

替比培南酯用途

Tebipenem Pivoxil是新型口服碳青霉烯类抗生素。

中文名	泰比培南酯
英文名	2,2-dimethylpropanoyloxymethyl (4R,5S,6S)-3-[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
中文别名	替比培南 \| 泰比培南匹酯 \| 替比培南匹伏酯 \| 替比培南酯
英文别名	更多

描述	Tebipenem Pivoxil是新型口服碳青霉烯类抗生素。
相关类别	信号通路 >> 抗感染 >> 细菌研究领域 >> 感染
参考文献	[1]. El-Gamal, M.I. and C.H. Oh, Current status of carbapenem antibiotics. Curr Top Med Chem, 2010. 10(18): p. 1882-97. [2]. Fujimoto, K., et al., Novel carbapenem antibiotics for parenteral and oral applications: in vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animals. Antimicrob Agents Chemother, 2013. 57(2): p. 697-707. [3]. Kato, K., et al., Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport. Mol Pharm, 2010. 7(5): p. 1747-56.

描述

Tebipenem Pivoxil是新型口服碳青霉烯类抗生素。

相关类别

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

参考文献

[1]. El-Gamal, M.I. and C.H. Oh, Current status of carbapenem antibiotics. Curr Top Med Chem, 2010. 10(18): p. 1882-97.

[2]. Fujimoto, K., et al., Novel carbapenem antibiotics for parenteral and oral applications: in vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animals. Antimicrob Agents Chemother, 2013. 57(2): p. 697-707.

[3]. Kato, K., et al., Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport. Mol Pharm, 2010. 7(5): p. 1747-56.

密度	1.5±0.1 g/cm3
沸点	661.9±65.0 °C at 760 mmHg
熔点	140-142℃
分子式	C₂₂H₃₁N₃O₆S₂
分子量	497.628
闪点	354.1±34.3 °C
精确质量	497.165436
PSA	159.34000
LogP	-0.45
外观性状	固体
蒸汽压	0.0±4.5 mmHg at 25°C
折射率	1.688
储存条件	室温

危害码 (欧洲)	Xi

Orapenem

1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[1-(4,5-dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (4R,5S,6S)-

Tebipenem pivoxil [INN]

Orapenem (TN)

S2159_Selleck

tebipenem pivoxil

[(2,2-Dimethylpropanoyl)oxy]methyl (4R,5S,6S)-3-{[1-(4,5-dihydro-1,3-thiazol-2-yl)-3-azetidinyl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

(4R,5R,6S)-3-[[1-(4,5-Dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy) methyl ester

Tebipenempivoxil

L-084