NNGH

更新时间：2025-08-25 11:33:43

NNGH结构式	常用名	NNGH	英文名	NNGH
	CAS号	161314-17-6	分子量	316.373
	密度	1.3±0.1 g/cm3	沸点	N/A
	分子式	C₁₃H₂₀N₂O₅S	熔点	N/A
	MSDS	美版	闪点	N/A

NNGH用途

NNGH是一种基质金属蛋白酶-1(MMP-3)抑制剂。MMP-3是Wnt/β-连环蛋白信号通路的直接转录靶点和必要贡献者。基质金属蛋白酶(MMP)在肿瘤进展的后期发挥着明确的作用[1]。

英文名	N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID
英文别名	更多

描述	NNGH是一种基质金属蛋白酶-1(MMP-3)抑制剂。MMP-3是Wnt/β-连环蛋白信号通路的直接转录靶点和必要贡献者。基质金属蛋白酶(MMP)在肿瘤进展的后期发挥着明确的作用[1]。
相关类别	研究领域 >> 癌症信号通路 >> 代谢酶/蛋白酶 >> MMP
参考文献	[1]. Laurence Blavier, et al. Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Cancer Biol Ther. 2010 Jul 15;10(2):198-208.

密度	1.3±0.1 g/cm3
分子式	C₁₃H₂₀N₂O₅S
分子量	316.373
精确质量	316.109283
LogP	1.94
InChIKey	JIRXORZYIXSWOB-UHFFFAOYSA-N
SMILES	COc1ccc(S(=O)(=O)N(CC(=O)NO)CC(C)C)cc1
外观性状	固体
折射率	1.547
储存条件	2-8°C

危险品运输编码	NONH for all modes of transport

Matrix metalloproteinase-3 causes dopaminergic neuronal death through Nox1-regenerated oxidative stress.

PLoS ONE 9(12) , e115954, (2014)

In the present study we investigated the interplay between matrix metalloproteinase 3 (MMP3) and NADPH oxidase 1 (Nox1) in the process of dopamine (DA) neuronal death. We found that MMP3 activation ca...

Matrix Metalloproteinase-3 Promotes Early Blood–Spinal Cord Barrier Disruption and Hemorrhage and Impairs Long-Term Neurological Recovery after Spinal Cord Injury

Am. J. Pathol. 184(11) , 2985-3000, (2014)

After spinal cord injury (SCI), blood–spinal cord barrier (BSCB) disruption by matrix metalloproteinases (MMPs) leads to BSCB permeability and blood cell infiltration, contributing to permanent neurol...

Hox10-regulated endodermal cell migration is essential for development of the ascidian intestine.

Dev. Biol. 403 , 43-56, (2015)

Hox cluster genes play crucial roles in development of the metazoan antero-posterior axis. Functions of Hox genes in patterning the central nervous system and limb buds are well known. They are also e...

Acetamide, N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-

N-Hydroxy-N2-isobutyl-N2-[(4-methoxyphenyl)sulfonyl]glycinamide

N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID