Tyrphostin AG 879结构式
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常用名 | Tyrphostin AG 879 | 英文名 | Tyrphostin AG 879 |
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CAS号 | 148741-30-4 | 分子量 | 316.461 | |
密度 | 1.1±0.1 g/cm3 | 沸点 | 432.7±55.0 °C at 760 mmHg | |
分子式 | C18H24N2OS | 熔点 | 232 °C | |
MSDS | 中文版 美版 | 闪点 | 215.5±31.5 °C |
Tyrphostin AG 879用途AG879是酪氨酸激酶的抑制剂,能够抑制TrKA的磷酸化,但不能抑制TrKB 和TrKC,也是高选择性的ErbB2激酶抑制剂。 |
中文名 | Tyrphostin AG 879 |
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英文名 | (E)-3-amino-2-[(3,5-ditert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile |
英文别名 | 更多 |
描述 | AG879是酪氨酸激酶的抑制剂,能够抑制TrKA的磷酸化,但不能抑制TrKB 和TrKC,也是高选择性的ErbB2激酶抑制剂。 |
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相关类别 | |
参考文献 |
密度 | 1.1±0.1 g/cm3 |
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沸点 | 432.7±55.0 °C at 760 mmHg |
熔点 | 232 °C |
分子式 | C18H24N2OS |
分子量 | 316.461 |
闪点 | 215.5±31.5 °C |
精确质量 | 316.160919 |
PSA | 102.13000 |
LogP | 4.76 |
外观性状 | 固体;Light yellow to Yellow to Orange powder to crystal |
蒸汽压 | 0.0±1.1 mmHg at 25°C |
折射率 | 1.600 |
储存条件 | Store at -20°C |
水溶解性 | DMSO: at 26 mg/mlsoluble |
个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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危险品运输编码 | NONH for all modes of transport |
WGK德国 | 3 |
海关编码 | 2930909090 |
海关编码 | 2930909090 |
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中文概述 | 2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0% |
申报要素 | 品名, 成分含量, 用途 |
Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Initiation of testicular tubulogenesis is controlled by neurotrophic tyrosine receptor kinases in a three-dimensional Sertoli cell aggregation assay.
Reproduction 136 , 459-69, (2008) The first morphological sign of testicular differentiation is the formation of testis cords. Prior to cord formation, newly specified Sertoli cells establish adhesive junctions, and condensation of so... |
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Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation.
Mol. Nutr. Food. Res. 52(7) , 815-22, (2008) In the present study, delphinidin was found to suppress the phosphorylation of the epidermal growth factor receptor (EGFR) within human tumour cells (human colon carcinoma cell line (HT29), human vulv... |
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The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation.
Cancer Biol. Ther. 3(1) , 96-101, (2004) AG 879 has been widely used as a Tyr kinase inhibitor specific for ErbB2 and FLK-1, a VEGF receptor. The IC(50) for both ErbB2 and FLK-1 is around 1 microM. AG 879, in combination of PP1 (an inhibitor... |
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