3-疏基丙酰基-beta-3-吡啶-d-ala-phe-gln-asn-cys-pro-arg-gly-nh2结构式
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常用名 | 3-疏基丙酰基-beta-3-吡啶-d-ala-phe-gln-asn-cys-pro-arg-gly-nh2 | 英文名 | (Deamino-Cys1,β-(3-pyridyl)-D-Ala2,Arg8)-Vasopressin trifluoroacetate salt |
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| CAS号 | 136105-89-0 | 分子量 | 1054.21000 | |
| 密度 | 1.56g/cm3 | 沸点 | N/A | |
| 分子式 | C45H63N15O11S2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
用途去氨基(D-3-(3′-吡啶基)-Ala2,Arg8)-加压素,一种加压素(AVP)的合成类似物,是抗利尿受体的弱激动剂。然而,去氨基(D-3-(3′-吡啶基)-Ala2,Arg8)-加压素是垂体促肾上腺皮质激素受体的有效激动剂[1]。 |
| 中文名 | 3-疏基丙酰基-beta-3-吡啶-d-ala-phe-gln-asn-cys-pro-arg-gly-nh2 |
|---|---|
| 英文名 | [deamino-Cys1, D-3-Pyridyl-Ala2, Arg8]-Vasopressin |
| 中文别名 | MPR-D-PYRIDYLALANINE-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2 |
| 英文别名 | 更多 |
| 描述 | 去氨基(D-3-(3′-吡啶基)-Ala2,Arg8)-加压素,一种加压素(AVP)的合成类似物,是抗利尿受体的弱激动剂。然而,去氨基(D-3-(3′-吡啶基)-Ala2,Arg8)-加压素是垂体促肾上腺皮质激素受体的有效激动剂[1]。 |
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| 相关类别 | |
| 靶点 |
Antidiuretic receptor; Pituitary corticotrope receptor[1] |
| 体外研究 | 去氨基(D-3-(3′-吡啶基)-Ala2,Arg8)-加压素(1 nM-10μM)对绵羊离体绵羊垂体前叶细胞有促肾上腺皮质激素释放活性[1]。 |
| 体内研究 | 去氨基(D-3-(3′-吡啶基)-Ala2,Arg8)-加压素(50μg/羊；静脉注射; 单剂量) 显示促肾上腺皮质激素释放活性[1]。 |
| 参考文献 |
| 密度 | 1.56g/cm3 |
|---|---|
| 分子式 | C45H63N15O11S2 |
| 分子量 | 1054.21000 |
| 精确质量 | 1053.43000 |
| PSA | 478.67000 |
| LogP | 1.21290 |
| 折射率 | 1.716 |
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Arginine vasopressin enhances pHi regulation in the presence of HCO3- by stimulating three acid-base transport systems.
Nature 337(6208) , 648-51, (1989) Growth factors raise intracellular pH (pHi) by stimulating Na+/H+ exchange in the absence of HCO3-. In mutant cells that lack the Na+/H+ exchange activity, this alkalinization does not occur, and the ... |
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Arginine vasopressin in advanced vasodilatory shock: a prospective, randomized, controlled study.
Circulation 107(18) , 2313-9, (2003) Vasodilatory shock is a potentially lethal complication of severe disease in critically ill patients. Currently, catecholamines are the most widely used vasopressor agents to support blood pressure, b... |
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Regulation of cyclooxygenase expression by vasopressin in rat renal medulla.
Endocrinology 145(3) , 1402-9, (2004) The antagonism between prostaglandin and vasopressin represents a classic negative feedback loop. It is not clear whether cyclooxygenase (COX)-2 and/or COX-1 expression is involved in elevated prostag... |
| 3-MERCAPTOPROPIONYL-β-3-PYRIDYL-D-ALA-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2 |
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