Camalexin

更新时间：2025-08-20 15:59:02

Camalexin结构式	常用名	Camalexin	英文名	Camalexin
	CAS号	135531-86-1	分子量	200.26000
	密度	N/A	沸点	N/A
	分子式	C₁₁H₈N₂S	熔点	N/A
	MSDS	中文版美版	闪点	N/A
	符号	GHS07	信号词	Warning

Camalexin用途

Camalexin 是一种植物抗毒素,是从 Camelina sativa 和 Arabidopsis(十字花科植物)中分离出来的,具有抗菌,抗真菌,抗增殖和抗癌活性。Camalexin 可诱导活性氧 (ROS) 的产生。

中文名	2-(1H-吲哚-3-基)噻唑
英文名	camalexin
英文别名	更多

描述	Camalexin 是一种植物抗毒素,是从 Camelina sativa 和 Arabidopsis(十字花科植物)中分离出来的,具有抗菌,抗真菌,抗增殖和抗癌活性。Camalexin 可诱导活性氧 (ROS) 的产生。
相关类别	研究领域 >> 癌症研究领域 >> 感染信号通路 >> 抗感染 >> 真菌信号通路 >> 抗感染 >> 细菌
靶点	Reactive oxygen species (ROS)[1][2]
体外研究	CAMILIXIN对人乳腺癌细胞系显示抗增殖活性〔2〕。对于oomycetes Phytophthora和腐霉NEP1样蛋白(坏死和乙烯诱导肽1样蛋白)是辣椒素合成和活性氧物种(ROS)形成的最初触发物。ROS似乎是樟脑素形成的普遍相关性。ROS的化学诱导,如应用氟虫胺,与樟脑素合成一致。在一个屏幕上,以增强对Alternaria油菜的敏感性,ESA1突变体被鉴定,显示延迟的樟脑素诱导。特别是响应于ROS诱导剂,合成樟脑素水平降低。ESA1的这一关键作用是由ESA1突变体不能响应于马尾松钩端螺旋体合成樟脑苷酸而证实的。一个额外的突变体,显示大大减少樟脑素积累是UPS1,这是孤立的基础上减少色氨酸生物合成酶的表达〔2〕。
参考文献	[1]. William A.Ayer, et al. Synthesis of camalexin and related phytoalexins. Tetrahedron. Volume 48, Issue 14, 1992, Pages 2919-2924. [2]. Glawischnig E. Camalexin. Phytochemistry. 2007 Feb;68(4):401-6. [3]. Mezencev R, et al. Antiproliferative and cancer chemopreventive activity of phytoalexins: focus on indole phytoalexins from crucifers. Neoplasma. 2003;50(4):239-45.

分子式	C₁₁H₈N₂S
分子量	200.26000
精确质量	200.04100
PSA	56.92000
LogP	3.29140
InChIKey	IYODIJVWGPRBGQ-UHFFFAOYSA-N
SMILES	c1ccc2c(-c3nccs3)c[nH]c2c1
储存条件	2-8°C，密闭，干燥

符号	GHS07
信号词	Warning
危害声明	H302-H315-H319-H335
警示性声明	P261-P305 + P351 + P338
危害码 (欧洲)	Xi
危险品运输编码	NONH for all modes of transport

TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASE-Mediated Generation and Metabolic Analysis of Camalexin-Deficient cyp71a12 cyp71a13 Double Knockout Lines.

Plant Physiol. 168 , 849-58, (2015)

In Arabidopsis (Arabidopsis thaliana), a number of defense-related metabolites are synthesized via indole-3-acetonitrile (IAN), including camalexin and indole-3-carboxylic acid (ICOOH) derivatives. Cy...

Identification of Multiple Phytotoxins Produced by Fusarium virguliforme Including a Phytotoxic Effector (FvNIS1) Associated With Sudden Death Syndrome Foliar Symptoms.

Mol. Plant Microbe Interact. 29 , 96-108, (2016)

Sudden death syndrome (SDS) of soybean is caused by a soilborne pathogen, Fusarium virguliforme. Phytotoxins produced by F. virguliforme are translocated from infected roots to leaves, in which they c...

Analysis of the Molecular Dialogue Between Gray Mold (Botrytis cinerea) and Grapevine (Vitis vinifera) Reveals a Clear Shift in Defense Mechanisms During Berry Ripening.

Mol. Plant Microbe Interact. 28 , 1167-80, (2015)

Mature grapevine berries at the harvesting stage (MB) are very susceptible to the gray mold fungus Botrytis cinerea, while veraison berries (VB) are not. We conducted simultaneous microscopic and tran...

2-(1H-indol-3-yl)thiazole

3-Thiazol-2-yl-1H-indole

Camalexin