缬沙坦-d3

• 常用名: 缬沙坦-d3
• 英文名: VALSARTAN-D3
• CAS号: 1331908-02-1
• 分子量: 438.537245334
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₆D₃N₅O₃
• 熔点: 84-89°C
• 闪点: N/A

缬沙坦-d3用途

缬沙坦-d3是氘标记的缬沙坦[1]。缬沙坦(CGP 48933)是一种血管紧张素II受体拮抗剂,具有研究高血压和心力衰竭的潜力[2]。

缬沙坦-d3名称

• 中文名: 缬沙坦-D3
• 英文名: VALSARTAN-D3

缬沙坦-d3生物活性

• 描述: 缬沙坦-d3是氘标记的缬沙坦[1]。缬沙坦(CGP 48933)是一种血管紧张素II受体拮抗剂,具有研究高血压和心力衰竭的潜力[2]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体
• 体外研究: 氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

  [2]. Shan H, et al. Valsartan ameliorates ageing-induced aorta degeneration via angiotensin II type 1 receptor-mediated ERK activity. J Cell Mol Med. 2014 Jun;18(6):1071-80.

  [3]. Wang Y, et al. Valsartan blocked alcohol-induced, Toll-like receptor 2 signaling-mediated inflammation in human vascular endothelial cells. Alcohol Clin Exp Res. 2014 Oct;38(10):2529-40.

  [4]. Sui X, et al. Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction. J Cell Mol Med. 2015 Aug;19(8):1773-82.

  [5]. Jiang Y, et al. Cardioprotective effect of valsartan in mice with short-term high-salt diet by regulating cardiac aquaporin 1 and angiogenic factor expression. Cardiovasc Pathol. 2015 Jul-Aug;24(4):224-9.

  [6]. Ping G, et al. Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice. Pharmacol Biochem Behav. 2014 Sep;124:5-12.

缬沙坦-d3物理化学性质

• 熔点: 84-89°C
• 分子式: C₂₄H₂₆D₃N₅O₃
• 分子量: 438.537245334
• 储存条件: -20°C Freezer