(-)-恩曲他滨-13C,15N2

• 常用名: (-)-恩曲他滨-13C,15N2
• 英文名: Emtricitabine-13C,15N2
• CAS号: 1217820-69-3
• 分子量: 250.23
• 密度: 1.8±0.1 g/cm3
• 沸点: N/A
• 分子式: C₇₁₃CH₁₀FN₁₅N₂O₃S
• 熔点: >145° C (dec.)
• 闪点: N/A

(-)-恩曲他滨-13C,15N2用途

（-）-恩曲他滨-13C，15N2是标记的恩曲他滨，可抑制HIV-1逆转录酶（HIV-1 RT）并通过掺入病毒基因组而导致病毒中DNA链延长的终止。 (-)-Emtricitabine-13C,15N2 is a labeled Emtricitabine which inhibits HIV-1 reverse transcriptase (HIV-1 RT) and can cause termination of DNA chain elongation in the virus via incorporation into the viral genome.

(-)-恩曲他滨-13C,15N2名称

• 中文名: (-)-恩曲他滨-13C,15N2
• 英文名: (-)-Emtricitabine-¹³C,¹⁵N2

(-)-恩曲他滨-13C,15N2生物活性

• 描述: 恩曲他滨-13C,15N2(BW1592-13C,15N2)是一种13C-和15N标记的恩曲他宾(HY-17427)。恩曲他滨是一种核苷逆转录酶抑制剂(NRTI),在PBMC细胞中的EC50为0.01μM。它是一种用于治疗艾滋病毒感染的抗病毒药物。
• 相关类别:
  研究领域 >> 感染
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注,因为它可能影响药物的药代动力学和代谢谱[1]
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.

  [2]. Xu P, et al. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692.

  [3]. Faltz M, et al. Effect of the Anti-retroviral Drugs Efavirenz, Tenofovir and Emtricitabine on Endothelial Cell Function: Role of PARP. Cardiovasc Toxicol. 2017 Jan 3. [Epub ahead of print]

  [4]. Szczech GM, Wang LH, Walsh JP, Reproductive toxicology profile of emtricitabine in mice and rabbits. Reprod Toxicol. 2003 Jan-Feb;17(1):95-108.

  [5]. Saag MS, et al. Emtricitabine, a new antiretroviral agent with activity against HIV and hepatitis B virus. Clin Infect Dis. 2006 Jan 1;42(1):126-31.

(-)-恩曲他滨-13C,15N2物理化学性质

• 密度: 1.8±0.1 g/cm3
• 熔点: >145° C (dec.)
• 分子式: C₇₁₃CH₁₀FN₁₅N₂O₃S
• 分子量: 250.23
• 精确质量: 250.040115
• 折射率: 1.731
• 储存条件: -20°C储存
• 水溶解性: Soluble in Ether and Methanol

(-)-恩曲他滨-13C,15N2英文别名

• 4-Amino-5-fluoro-1-[(2R,5S)-2-hydroxymethyl)-1,3-oxathiolan-5-yl]-2-(1H-pyrimidinone-13C,15N2
• BW 1592-13C,15N2
• BW 524W91-13C,15N2
• Coviracil-13C,15N2
• 2(1H)-Pyrimidinone-2-13C-1,3-15N2, 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-
• (-)-2'-Deoxy-5-fluoro-3'-thiacytidine-13C,15N2
• 4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-(2-13C,15N2)pyrimidinone
• (-)-2',3'-Dideoxy-5-fluoro-3'-thiacytidine-13C,15N2