TCO-NHS ester结构式
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常用名 | TCO-NHS ester | 英文名 | TCO-NHS ester |
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CAS号 | 1191901-33-3 | 分子量 | 267.278 | |
密度 | 1.3±0.1 g/cm3 | 沸点 | 369.1±45.0 °C at 760 mmHg | |
分子式 | C13H17NO5 | 熔点 | N/A | |
MSDS | 中文版 美版 | 闪点 | 177.0±28.7 °C |
TCO-NHS ester用途本网站展示的所有产品仅用作科学研究,不可食用,不可用于人体或动物的临床诊断和治疗。
TCO-NHS ester 是一种 PROTAC linker,属于 alkyl/ether 类。可用于合成 PROTAC 分子。 |
中文名 | TCO-NHS酯 |
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英文名 | 1-({[(4Z)-4-Cycloocten-1-yloxy]carbonyl}oxy)-2,5-pyrrolidinedione |
英文别名 | 更多 |
描述 | TCO-NHS ester 是一种 PROTAC linker,属于 alkyl/ether 类。可用于合成 PROTAC 分子。 |
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相关类别 | |
靶点 |
Alkyl/ether |
体外研究 | PROTACs包含两种不同的配体,它们通过连接体连接;一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。 |
参考文献 |
密度 | 1.3±0.1 g/cm3 |
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沸点 | 369.1±45.0 °C at 760 mmHg |
分子式 | C13H17NO5 |
分子量 | 267.278 |
闪点 | 177.0±28.7 °C |
精确质量 | 267.110687 |
LogP | 1.45 |
蒸汽压 | 0.0±0.8 mmHg at 25°C |
折射率 | 1.540 |
储存条件 | -20°C,存于惰性气体中,避光 |
危害码 (欧洲) | Xi |
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危险品运输编码 | NONH for all modes of transport |
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Bioconjug. Chem. 22 , 2263-2270, (2011) 1,2,4,5-Tetrazines have been established as effective dienes for inverse electron demand [4 + 2] Diels-Alder cycloaddition reactions with strained alkenes for over 50 years. Recently, this reaction pa... |
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Tetrazine-based cycloadditions: application to pretargeted live cell imaging.
Bioconjug. Chem. 19 , 2297-2299, (2008) Bioorthogonal tetrazine cycloadditions have been applied to live cell labeling. Tetrazines react irreversibly with the strained dienophile norbornene forming dihydropyrazine products and dinitrogen. T... |
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Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.
J. Am. Chem. Soc. 130 , 13518-13519, (2008) Described is a bioorthogonal reaction that proceeds with unusually fast reaction rates without need for catalysis: the cycloaddition of s-tetrazine and trans-cyclooctene derivatives. The reactions tol... |
1-({[(4Z)-4-Cycloocten-1-yloxy]carbonyl}oxy)-2,5-pyrrolidinedione |
2,5-Pyrrolidinedione, 1-[[[(4Z)-4-cycloocten-1-yloxy]carbonyl]oxy]- |