丙烯腈

常用名 丙烯腈 英文名 Acrylonitrile
CAS号 107-13-1 分子量 53.063
密度 0.8±0.1 g/cm3 沸点 77.3±0.0 °C at 760 mmHg
分子式 C3H3N 熔点 -83.5 °C
MSDS丙烯腈的MSDS|SDS|pdf下载 中文版 美版 闪点 0.0±0.0 °C
符号 GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
信号词 Danger

 丙烯腈用途


1.丙烯腈是合成纤维,合成橡胶和合成树脂的重要单体。由丙烯腈制得聚丙烯腈纤维即(腈纶),其性能极似羊毛,因此也叫(合成羊毛)。丙烯腈与丁二烯共聚可制得丁腈橡胶,具有良好的耐油性,耐寒性,耐磨性,和电绝缘性能,并且在大多数化学溶剂,阳光和热作用下,性能比较稳定。丙烯腈与丁二烯,苯乙烯共聚制得ABS树脂,具有质轻,耐寒,抗冲击性能较好等优点。丙烯腈水解可制得丙烯酰胺和丙烯酸及其酯类。它们是重要的有机化工原料,丙烯腈还可电解加氢偶联制得己二腈,由己二腈加氢又可制得己二胺,己二胺是尼龙66原料。可制造抗水剂和胶粘剂等,也用于其他有机合成和医药工业中,并用作谷类熏蒸剂等。此外,本品也是一种非质子型极性溶剂。用作色谱分析标准物质,也用于橡胶、塑料、有机合成及杀虫剂的制造。丙烯腈是杀菌剂溴菌腈、霜霉威,杀虫剂毒死蜱和杀虫双、杀螟丹的中间体,还可以制备二氯菊酸甲酯用以生产拟除虫菊酯,也是杀虫剂虫满腈的中间体。

2.为重要的有机合成单体,主要用于生产聚丙烯腈纤维(腈纶),还用于制造丁腈橡胶和丁腈胶乳、ABS树脂、丙烯酰胺、丙烯酸、己二腈、丁二腈、次甲基戊二腈、溴二酸等重要产品。也是制造医药、染料、农药、食品添加剂、抗氧剂、表面活性剂的原料。作为硬单体,用于制造丙烯酸酯乳液型胶黏剂。

3.色谱分析参比物质,橡胶合成。塑料合成,有机合成表面活性及抗氧剂,杀虫剂的制造。

4.用于制造聚丙烯腈、丁腈橡胶、染料、合成树脂、医药等。

更多

 丙烯腈物理化学性质

[ 密度 ]: 0.8±0.1 g/cm3
[ 沸点 ]: 77.3±0.0 °C at 760 mmHg
[ 熔点 ]: -83.5 °C
[ 分子式 ]: C3H3N
[ 分子量 ]: 53.063
[ 闪点 ]: 0.0±0.0 °C
[ 精确质量 ]: 53.026550
[ PSA ]: 23.79000
[ LogP ]: 0.19
[ 外观性状 ]: 透明液体
[ 蒸汽密度 ]: 1.83 (vs air)
[ 蒸汽压 ]: 97.1±0.1 mmHg at 25°C
[ 折射率 ]: 1.385
[ 储存条件 ]:

1.储存注意事项 通常商品加有稳定剂。储存于阴凉、通风良好的专用库房内,实行“双人收发、双人保管”制度。远离火种、热源。库温不宜超过37℃。包装要求密封,不可与空气接触。应与氧化剂、酸类、碱类、食用化学品分开存放,切忌混储。不宜大量储存或久存。采用防爆型照明、通风设施。禁止使用易产生火花的机械设备和工具。储区应备有泄漏应急处理设备和合适的收容材料。

2.本品采用铁桶包装。贮存容器要密封,仓库要有良好的通风,防止日晒,要远离硫酸、硝酸等强酸性物质。按“危险品规定”贮运。

[ 稳定性 ]:

1.化学性质:化学性质活泼,能发生双键加成反应,与相应的含有活泼氢的无机或有机化合物反应制成一系列氰乙基化产物。在缺氧或暴露在可见光情况下易聚合,在浓碱存在下能强烈聚合。与还原剂发生激烈反应,放出有毒气体。蒸气与空气混合易形成爆炸性混合物,与氧化剂发生强烈反应,遇明火、高热会引起燃烧爆炸。见光、遇热、久贮易聚合,有燃烧爆炸危险。

2.本品极毒,对温血动物的毒性约为氰化氢的1/30。丙烯腈不仅蒸气有毒,而且附着于皮肤上也易经皮肤中毒。对小鼠静脉注射LD5015mg/kg,大鼠LD50为93mg/kg。长时间吸入稀丙烯腈蒸气,则能引起恶心、呕吐、头痛、疲倦和不适等症状。工作场所最高容许浓度为45mg/m3。生产设备要密闭,操作时要戴防护用具。丙烯腈若溅到衣服上应立即脱下衣服,溅及皮肤时用大量水冲洗。溅入眼内,需用流水冲洗15分钟以上。不慎吞入时,则用温盐水洗胃。如果中毒,应立即用硫代硫酸钠、亚硝酸钠进行静脉注射,并请医生诊治。

3.稳定性 稳定

4.禁配物 强氧化剂、碱类、酸类

5.避免接触的条件 受热、光照、接触空气

6.聚合危害 聚合

7.分解产物 氰化氢

[ 水溶解性 ]: Soluble. 7.45 g/100 mL
[ 分子结构 ]:

1、摩尔折射率:15.58

2、摩尔体积(cm3/mol):66.5

3、等张比容(90.2K):148.8

4、表面张力(dyne/cm):25.0

5、介电常数:

6、偶极距(10-24cm3):

7、极化率:6.17

[ 计算化学 ]:

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:0

3.氢键受体数量:1

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积23.8

7.重原子数量:4

8.表面电荷:0

9.复杂度:54.9

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

[ 更多 ]:

1.性状:无色液体,有刺激性气味。

2.pH值:6~7.5(5%溶液)

3.熔点(℃):-83.6

4.沸点(℃):77.3

5.相对密度(水=1):0.81

6.相对蒸气密度(空气=1):1.83

7.饱和蒸气压(kPa):11.07(20℃)

8.燃烧热(kJ/mol):-1761.5

9.临界温度(℃):246

10.临界压力(MPa):3.54

11.辛醇/水分配系数:0.25

12.闪点(℃):-1(CC)

13.引燃温度(℃):481

14.爆炸上限(%):17.0

15.爆炸下限(%):3.0

16.溶解性:微溶于水,易溶于多数有机溶剂。

17.折射率(20ºC):1.3911

18.黏度(mPa·s,25ºC):0.34

 丙烯腈MSDS

国标编号: 32162
CAS: 107-13-1
中文名称: 丙烯腈
英文名称: acrylonitrile;cyanoethylene
别 名: 乙烯基氰;氰(基)乙烯
分子式: C3H3N;CH2CHCN
分子量: 53.06
熔 点: -83.6℃ 沸点:77.3℃
密 度: 相对密度(水=1)0.81;
蒸汽压: -5℃
溶解性: 微溶于水,易溶于多数有机溶剂
稳定性: 稳定
外观与性状: 无色液体,有桃仁气味
危险标记: 7(易燃液体),40(有毒品)
用 途: 用于制造聚丙烯腈、丁腈橡胶、染料、合成树脂、医药等

2.对环境的影响:
一、健康危害
侵入途径:吸入、食入、经皮吸收。
健康危害:本品在体内析出氰根,抑制呼吸酶;对呼吸中枢有直接麻醉作用。急性中毒表现与氢氰酸相似。
急性中毒:以中枢神经系统症状为主,伴有上呼吸道和眼部刺激症状。轻度中毒有头晕、头木、意识蒙胧及口唇紫绀等。眼结膜及鼻、咽部充血。重者除上述症状加重外,出现四肢阵发性强直抽搐、昏迷。液体污染皮肤,可致皮炎,局部出现红斑、丘疹或水疱。
慢性中毒:尚无定论。长期接触,部分工人出现神衰综合征、低血压等。对肝脏影响未肯定。
二、毒理学资料及环境行为
毒性:属高毒类。
急性毒性:LD 5078mg/kg(大鼠经口);250mg/kg(兔经皮);人吸入300~500mg/m 3×5~10分钟,上呼吸道灼痛、流泪;人吸入35~200mg/m 3×20~45分钟,粘膜刺激。
亚急性和慢性毒性:大鼠吸入40mg/m 3×4小时/日×6日/周×40日,致死,肝坏死;大鼠经口0.1%饮水×13周,生长减慢,萎靡。
刺激性:家兔经眼:20mg(24小时),重度刺激。家兔经皮:500mg,轻度刺激。
致突变性:微生物致变突性:鼠伤寒沙门氏菌25µL/皿。哺乳动物体细胞突变性:人淋巴细胞25mg/L。
生殖毒性:大鼠经口最低中毒剂量(TDL 0):650mg/kg(孕6~15天),对雄性生育指数有影响,可引起胚胎毒性,肌肉骨骼发育异常。
致癌性:大鼠经口最小中毒剂量1700mg/kg(37周)胃癌。
污染来源:丙烯腈是重要的有机原料,主要用于橡胶合成(如丁腈橡胶)、塑料合成(如ABS,AS树脂、聚丙烯酰胺等)、有机合成、制造腈纶、尼龙66等膈成纤维、杀虫剂、抗水剂、粘合剂等;还用合适谷物烟薰剂。从事丙烯腈生产及以丙烯腈为原料合成和制造上述物质的企业均是丙烯腈污染的主要来源。腈纶纤维燃烧时可释放也丙烯腈。
丙烯腈在水中是不稳定的,水中浓度1mg/L以下时不影响生物降解。当水中丙烯腈的浓度为10mg/L时,经过一昼夜剩下46%,二昼夜只剩下19%,四昼夜剩下5%,六昼夜只剩下3.6%当水中丙烯脯的浓度为75mg/L时,经过二昼夜剩下30.5%,六昼夜时为起初数量的4.5%。空气中嗅觉阈值浓度为1.7~23ppm,水中嗅觉阈值浓度为0.0031~50.4mg/L。
危险特性:易燃,其蒸气与空气可形成爆炸性混合物。遇明火、高热易燃烧,并放出有毒气体。与氧化剂、强酸、强碱、胺类、溴反应剧烈。在火场高温下,能发生聚合放热,使容器破裂。
燃烧(分解)产物:一氧化碳、二氧化碳、氧化氮、氰化氢。

3.现场应急监测方法:
快速检测管法;便携式气相色谱法《突发性环境污染事故应急监测与处理处置技术》万本太主编
直接进水样气相色谱法;气体检测管法
气体速测管(德国德尔格公司产品)

4.实验室监测方法:
监测方法 来源 类别
气相色谱法 HJ/T37-1999 固定污染源排气
吡啶-苯胺比色法 《空气中有害物质的测定方法》(第二版),杭士平编 空气
纳氏试剂比色法 《化工企业空气中有害物质测定方法》化学工业出版社 化工企业空气
纳氏试剂比色法 《水质分析大全》张宏陶等编 水质
气相色谱法 《固体废弃物试验与分析评价手册》中国环境监测总站等译 固体废弃物

5.环境标准:

中国 (TJ36-79) 车间空气中有害物质的最高容许浓度 2mg/m3[皮]
中国 (TJ36-79) 居住区大气中有害物质的最高容许浓度 0.05mg/m3(日均值)
中国(GB16297-1996) 大气污染物综合排放标准 最高允许排放浓度:22mg/m3(表2);26mg/m3(表1)
最高允许排放速率(kg/h):二级0.77~16(表2);0.91~19(表1);三级1.2~25(表2);1.4~29(表1)
无组织排放监控浓度限值(mg/m3):0.60(表2);0.75(表1)
中国(待颁布) 饮用水源中有害物质的最高容许浓度 2.0mg/L
中国(GB11607-89) 渔业水质标准 0.5mg/L
中国(GHZB1-1999) 地表水环境质量标准(I、II、III类水域特定值) 0.000058mg/L
中国(GB8978-1996) 污水综合排放标准 一级:2.0mg/L
二级:5.0mg/L
三级:5.0mg/L

6.应急处理处置方法:
一、泄漏应急处理
迅速撤离泄漏污染区人员至安全区,并进行隔离,严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器,穿防毒服。尽可能切断泄漏源,防止进入下水道、排洪沟等限制性空间。小量泄漏:用活性炭或其它惰性材料吸收。也可用大量水冲洗,洗水稀释后放入废水系统。大量泄漏:构筑围堤或挖坑收容;用泡沫覆盖,降低蒸气灾害。喷雾状水冷却和稀释蒸气、保护现场人员、把泄漏物稀释成不燃物。用防爆泵转移至槽车或专用收集器内,回收或运至废物处理场所处置。废弃物处置方法:焚烧法,焚烧炉要有后燃烧室,焚烧炉排出的氮氧化物通过洗涤器除去。化学法,用乙醇氢氧化钠处理,将其产物同大量水一起排入下水道。另外,从废水中回收丙烯腈也是一种可考虑的处理办法。
二、防护措施
呼吸系统防护:可能接触毒物时,必须佩戴过滤式防毒面具(全面罩)。紧急事态抢救或撤离时,佩戴空气呼吸器。
眼睛防护:呼吸系统防护中已作防护。
身体防护:穿连衣式胶布防毒衣。
手防护:戴橡胶手套。
其它:工作现场禁止吸烟、进食和饮水。工作毕,彻底清洗。单独存放被毒物污染的衣服,洗后备用。车间应配备急救设备及药品。作业人员应学会自救互救。
三、急救措施
皮肤接触:立即脱去被污染的衣着,用流动清水或5%硫代硫酸钠溶液彻底冲洗至少20分钟。就医。
眼睛接触:提起眼睑,用流动清水或生理盐水冲洗。就医。
吸入:迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难,给输氧。呼吸心跳停止时,立即进行人工呼吸(勿用口对口)和胸外心脏按压术。给吸入亚硝酸异戊酯,就医。
食入:饮足量温水,催吐,用1:5000高锰酸钾或5%硫代硫酸钠溶液洗胃。就医。
灭火方法:消防人员必须佩戴过滤式防毒面具(全面罩)或隔离式呼吸器、穿全身防火防毒服,在上风处灭火。灭火剂:二氧化碳、干粉、砂土。用水灭火无效,但须用水保持火场容器冷却。

 丙烯腈毒性和生态

丙烯腈毒理学数据:

1.急性毒性

LD50:78mg/kg(大鼠经口);27mg/kg(小鼠经口);148mg/kg(大鼠经皮);63mg/kg(兔经皮)

LC50:333ppm(大鼠吸入,4h)

2.刺激性

家兔经皮:500mg,轻度刺激。

家兔经眼:20mg,重度刺激。

3.亚急性与慢性毒性 大鼠、豚鼠、兔和猫在330mg/m3下吸入,每天4h,每周5天,在4周内半数动物死亡;在220mg/m3浓度下,10周,除出现呼吸道症状外,未出现明显中毒症状。

4.致突变性 微生物致突变性:鼠伤寒沙门菌25μl/皿。哺乳动物体细胞突变性:人淋巴细胞25mg/L。

人吸入0.8mg/m3(146周),导致DNA损伤、精子形态学和细胞遗传学改变。

5.致畸性 雌性大鼠孕后8d腹腔内注射641mg/kg,导致仔鼠中枢神经系统和肌肉骨骼系统畸形。

6.致癌性 IARC致癌性评论:G2B,可疑人类致癌物。

7.其他 大鼠经口最低中毒剂量(TDLo):650mg/kg(孕6~15d),对雌性生育指数有影响,可引起胚胎毒性,肌肉骨骼发育异常。

丙烯腈生态学数据:

1.生态毒性

LC50:2.6mg/L(30d)(黑头呆鱼,静态);10.1mg/L(96h)(黑头呆鱼,动态);11.8mg/L(48h)(蓝鳃太阳鱼,静态);13mg/L(24h),7.6mg/L(48h)(水蚤)

2.生物降解性

好氧生物降解(h):30~552

厌氧生物降解(h):120~2208

3.非生物降解性

光解最大光吸收(nm):203

空气中光氧化半衰期(h):13.4~189

一级水解半衰期(h):1.06×107

4.生物富集性 蓝鳃太阳鱼,在流动水中接触48h,BCF为48。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AT5250000
CHEMICAL NAME :
Acrylonitrile
CAS REGISTRY NUMBER :
107-13-1
BEILSTEIN REFERENCE NO. :
0605310
LAST UPDATED :
199806
DATA ITEMS CITED :
139
MOLECULAR FORMULA :
C3-H3-N
MOLECULAR WEIGHT :
53.07
WISWESSER LINE NOTATION :
NC1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Non-standard exposure
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
16 ppm/20M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
1 gm/m3/1H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
2015 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
78 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
425 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
148 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Endocrine - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
27 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
46 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - corneal damage Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
110 ppm/4H
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Behavioral - coma
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LC - Lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
>90 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
600 ppm/4H
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
260 ppm/4H
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - coma Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
63 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
69 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis with appropriate anesthesia Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
575 ppm/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - cough
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
202 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis with appropriate anesthesia Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10920 mg/kg/1Y-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2100 mg/kg/21D-C
TOXIC EFFECTS :
Endocrine - other changes Nutritional and Gross Metabolic - changes in sodium
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
120 mg/kg/60D-I
TOXIC EFFECTS :
Endocrine - adrenal cortex hyperplasia Endocrine - changes in adrenal weight Blood - other changes
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 ug/m3/5H/26W-I
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
330 mg/kg/4H/8W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3751 mg/kg/19W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
945 mg/kg/90D-C
TOXIC EFFECTS :
Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
99 mg/kg/3D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
900 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Musculoskeletal - other changes
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
330 mg/kg/4H/8W-I
TOXIC EFFECTS :
Behavioral - muscle weakness Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
330 mg/m3/4H/8W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
330 mg/m3/4H/8W-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
330 mg/m3/4H/8W-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18200 mg/kg/52W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Brain and Coverings - tumors
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 ppm/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 ppm/4H/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors
TYPE OF TEST :
TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
40 ppm/4H/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3640 mg/kg/52W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Gastrointestinal - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
650 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
650 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
644 mg/kg
SEX/DURATION :
male 2 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
40 ppm/6H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
80 ppm/6H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
25 ppm/6H
SEX/DURATION :
female 6-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
600 mg/kg
SEX/DURATION :
male 60 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
32 mg/kg
SEX/DURATION :
female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
641 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
641 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
641 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
DNA adduct
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :
DNA adduct
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 51,167,1984 *** REVIEWS *** ACGIH TLV-Suspected human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 4.3 mg/m3 (2 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,79,1987 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,73,1979 IARC Cancer Review:Group 2A IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,79,1987 TOXICOLOGY REVIEW CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- Volume(issue)/page/year: 10(3),49,1973 TOXICOLOGY REVIEW SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- Volume(issue)/page/year: 22,327,1980 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 20 ppm (45 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,6,1971 OSHA PEL (Construc):8H TWA 20 ppm (45 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 39,1926.55,1994 OSHA PEL (Fed Cont):8H TWA 20 ppm (45 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 OSHA-cancer hazard CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1045,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 2 ppm;Skin JAN 1993 OEL-AUSTRALIA:TWA 2 ppm (4.5 mg/m3);Skin;Carcinogen JAN 1993 OEL-BELGIUM:TWA 2 ppm (4.3 mg/m3);Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 2 ppm (4 mg/m3);Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 2 ppm (4.5 mg/m3);STEL 4 ppm;Skin;Carcinogen JAN 1993 OEL-FRANCE:TWA 2 ppm (4.5 mg/m3);STEL 15 ppm;Carcinogen JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-HUNGARY:STEL 0.5 mg/m3;Skin;Carcinogen JAN 1993 OEL-INDIA:TWA 2 ppm (4.5 mg/m3);Skin;Carcinogen JAN 1993 OEL-JAPAN:TWA 2 ppm (4.3 mg/m3);Skin;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 4 ppm (9 mg/m3);STEL 10 ppm;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 20 ppm (45 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 10 mg/m3 JAN 1993 OEL-RUSSIA:TWA 2 ppm;STEL 0.5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 2 ppm (4.5 mg/m3);STEL 6 ppm;Skin;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (4.5 mg/m3);Skin;Carcinogen JAN 1993 OEL-TURKEY:TWA 20 ppm (45 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (4 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ACRYLONITRILE-air:8H CA TWA 1 ppm;CL 10 ppm/15M (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 03800 No. of Facilities: 3610 (estimated) No. of Industries: 45 No. of Occupations: 55 No. of Employees: 55698 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 03800 No. of Facilities: 2522 (estimated) No. of Industries: 24 No. of Occupations: 39 No. of Employees: 81691 (estimated) No. of Female Employees: 27358 (estimated)

 丙烯腈安全信息

[ 符号 ]: GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
[ 信号词 ]: Danger
[ 危害声明 ]: H225-H301 + H311 + H331-H350-H370
[ 警示性声明 ]: P201-P210-P260-P280-P301 + P310-P311
[ 个人防护装备 ]: Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]: F:Flammable
[ 风险声明 (欧洲) ]: R11;R23/24/25;R37/38;R41;R43;R45;R51/53
[ 安全声明 (欧洲) ]: S53-S9-S16-S45-S61-S36/37
[ 危险品运输编码 ]: UN 1093 3/PG 1
[ WGK德国 ]: 3
[ RTECS号 ]: AT5250000
[ 包装等级 ]: I
[ 危险类别 ]: 3
[ 海关编码 ]: 2926100000

 丙烯腈合成线路

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 丙烯腈制备

1.氰乙醇法 环氧乙烷和氢氰酸在水和三甲胺的存在下反应得氰乙醇,然后以碳酸镁为催化剂,于200-280℃脱水制得丙烯腈,收率约75%。此法生产的丙烯腈纯度较高,但氢氰酸毒性大,成本也较高。2.乙炔法 乙炔和氢氰酸在氯化亚铜-氯化钾-氯化钠稀盐酸溶液的催化作用下在80-90℃反应得丙烯腈此法生产过程简单,收率良好,以氢氰酸计可达97%。但副反应多,产物精制较难,毒性也大,且原料乙炔价格高于丙烯,在技术和经济上落后于丙烯氨氧化法。1960年以前,该法是世界各国生产丙烯腈的主要方法。3.丙稀氨氧化法以丙烯、氨、空气和水为原料,按其一定量配比进入沸腾床或固定床反应器,在以硅胶作载体的磷钼鉍系或锑铁系催化剂作用下,在400-500℃温度和常压下,生成丙烯腈。然后经中和塔用稀硫酸除去未反应的氨,再经吸收塔用水吸收丙烯腈等气体,形成水溶液,使该水溶液经萃取塔分离乙腈,在脱氢氰酸塔除去氢氰酸,经脱水、精馏而得丙烯腈产品,其单程收率可达75%,副产品有乙腈、氢氰酸和硫铵。此法是目前最有工业生产价值的生产方法。

2.其制备方法主要用丙烯氨氧化法,以丙烯、氨气和空气中的氧气为原料,在催化剂存在下进行反应,催化剂主要是含磷、钼、铋系的化合物,丙烯、氨和空气的摩尔比为1∶(1~1.2)∶(1.8~2.3),反应温度为400~500℃,反应压力为常压,反应器为流化床。107-13-1 preparation
该反应丙烯腈的单程收率60%~75%。

3.环氧乙烷法 由环氧乙烷和氢氰酸在水和三甲胺的存在下反应制得氰乙醇;然后以碳酸镁为催化剂,于200~280℃脱水制得丙烯腈:

107-13-1 preparation

4.乙炔法 由乙炔与氢氰酸作用而得,反应为常压,温度80~90℃,用氯化亚铜和氯化铵为催化剂。该法特点是生产过程简单,但副产物种类较多,不易分离。主反应式如下:

107-13-1 preparation

5.丙烯氨氧化法 以丙烯、氨氧和空气中的氧为原料制得,主要副产物为氢氰酸、乙腈、丙烯醛、CO2和CO。主反应如下:
107-13-1 preparation

将原料气体以丙烯∶氨∶空气=1.0∶1.15∶10.5(mol)的比例从底部进入流化床反应器,反应温度440℃,压力63.74kPa。反应热用软水循环回收发生高压蒸汽。反应气体冷却后,洗涤、吸收、精馏后得到高纯度产品。该方法是目前国内外主要的生产方法。

 丙烯腈海关

[ 海关编码 ]: 2926100000
[ 中文概述 ]: 2926100000 丙烯腈〔即2-丙烯腈、乙烯基氰〕。监管条件:X(有毒化学品环境管理放行通知单)。增值税率:17.0%。退税率:13.0%。最低关税:6.5%。普通关税:30.0%
[申报要素 ]: 品名, 成分含量, 用途
[ 监管条件 ]: X.有毒化学品环境管理放行通知单
[ Summary ]: 2926100000 acrylonitrile。supervision conditions:x(environment control release notice for poisonous chemicals)。VAT:17.0%。tax rebate rate:13.0%。MFN tarrif:6.5%。general tariff:30.0%

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