马沙骨化醇

• 常用名: 马沙骨化醇
• 英文名: Maxacalcitol
• CAS号: 103909-75-7
• 分子量: 418.609
• 密度: 1.1±0.1 g/cm3
• 沸点: 581.4±50.0 °C at 760 mmHg
• 分子式: C₂₆H₄₂O₄
• 熔点: N/A
• 闪点: 305.4±30.1 °C

马沙骨化醇用途

Maxacalcitol (22-Oxacalcitriol)是维生素D3类似物。

马沙骨化醇名称

• 中文名: 马沙骨化醇
• 英文名: (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

马沙骨化醇生物活性

• 描述: Maxacalcitol (22-Oxacalcitriol)是维生素D3类似物。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Barroga, et al. Inhibitory effects of 22-oxa-calcitriol and all-trans retinoic acid on the growth of a canine osteosarcoma derived cell-line in vivo and its pulmonary metastasis in vivo. Res.Vet.Sci. (2000)68 79.

  [2]. Monier-Faugere, et al. 22-Oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure. Kidney Int. (1999)55 821.

  [3]. Inoue K, et al. Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3.Lab Invest. 2012 Aug 27.

  [4]. Karashima T, et al. Successful Treatment of Bowen's Disease with Topical Maxacalcitol.Acta Derm Venereol. 2012 Jan 26.

马沙骨化醇物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 581.4±50.0 °C at 760 mmHg
• 分子式: C₂₆H₄₂O₄
• 分子量: 418.609
• 闪点: 305.4±30.1 °C
• 精确质量: 418.308319
• PSA: 69.92000
• LogP: 4.38
• 蒸汽压: 0.0±3.7 mmHg at 25°C
• 折射率: 1.549
• 储存条件: 2-8℃

马沙骨化醇英文别名

• Oxarol
• (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
• (1S,3R,5Z,7E,20S)-20-(3-hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol
• 1α,25-Dihydroxy-22-oxavitamin D3
• MC 1275
• Maxacalcitol
• (1S,3R,5Z,7E,9ξ)-20-(3-hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol
• 1,25-dihydroxy-22-oxavitamin D3
• 22-Oxacalcitriol
• (1S,3R,5Z,7E,9ξ,20S)-20-(3-Hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol
• 1,3-cyclohexanediol, 4-methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-
• Prezios
• (1S-(1a(R*),3ab,4E(1S*,3R*,5Z),7aa))-4-Methylene-5-(2-(octahydro-1-(1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyl-4H-inden-4-ylidene)ethylidene)-1,3-cyclohexanediol
• 22-Oxa-1,25-dihydroxyvitamin D3
• 1alpha,25-Dihydroxy-22-oxavitamin D3
• 1R,25-dihydroxy-22-oxavitamin D3
• 1a,25-Dihydroxy-22-oxavitamin D3
• 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-