1-[(4R,5R)-4,5-二羟基-L-鸟氨酸]棘白菌素 B 盐酸盐

• 常用名: 1-[(4R,5R)-4,5-二羟基-L-鸟氨酸]棘白菌素 B 盐酸盐
• 英文名: 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B hydrochloride (1:1)
• CAS号: 1029890-89-8
• 分子量: 834.268
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₄H₅₂ClN₇O₁₅
• 熔点: N/A
• 闪点: N/A

用途

A-30912A盐酸细胞核是棘白菌素B(ECB)脱酰酶催化的反应产物[1]。

名称

• 中文名: 1-[(4R,5R)-4,5-二羟基-L-鸟氨酸]棘白菌素 B 盐酸盐
• 英文名: (2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-Amino-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methylhexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25(9H,25aH)-hexone hydrochloride (1:1)

生物活性

• 描述: A-30912A盐酸细胞核是棘白菌素B(ECB)脱酰酶催化的反应产物[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 其他 >> 其他
• 体外研究: 棘白菌素B(ECB)是由巢状曲霉(Aspergillus nidulans)和rugulosus曲霉(Aspergillus rugulosus)发酵获得的天然环六肽之一,具有亚油酸侧链,可抑制真菌细胞壁生物合成中的关键酶β-(1,3)-D-葡聚糖合酶[1]。
• 参考文献:

  [1]. Lei Shao, et al. Efficient bioconversion of echinocandin B to its nucleus by overexpression of deacylase genes in different host strains. Appl Environ Microbiol. 2013 Feb;79(4):1126-33.

物理化学性质

• 分子式: C₃₄H₅₂ClN₇O₁₅
• 分子量: 834.268
• 精确质量: 833.320984
• 储存条件: 室温，干燥，密封

安全信息

• 危害码 (欧洲): Xi

英文别名

• (2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-Amino-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methylhexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25(9H,25aH)-hexone hydrochloride (1:1)
• 1H-Dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacycloheneicosine-5,8,14,19,22,25(9H,25aH)-hexone, 9-amino-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]hexadecahydro-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-, (2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-, hydrochloride (1:1)