361440-67-7

• 常用中文名：(1S,3S,5S)-3-(氨基羰基)-2-氮杂双环[3.1.0]己烷-2-甲酸叔丁酯
• 常用英文名：(1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester
• CAS号：361440-67-7
• 分子式：C₁₁H₁₈N₂O₃
• 分子量：226.272
• 相关类别： 医药中间体 原料药中间体
• 发布时间：2018-11-29 17:03:52
• 更新时间：2026-07-01 11:29:23

名称

• 中文名: (1S,3S,5S)-3-(氨基羰基)-2-氮杂双环[3.1.0]己烷-2-甲酸叔丁酯
• 英文名: (1S,3S,5S)-tert-Butyl 3-carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate
• 中文别名: (1S,3S,5S)-2-Boc-2-氮杂双环[3.1.0]己烷-3-甲酰胺; 沙格列中间体; Monoclonal Antibody to GPC3抗体(别名:SGB; 1S,3S,5S)-3-(氨基羰基)-2-氮杂双环[3.1.0]己烷-2-甲酸叔丁酯,沙克列汀中间体; (1S,3S,5S)-3-(氨基羰基)-2-氮杂双环[3.1.0]已烷-2-甲酸叔丁酯; 重组人 GPC3蛋白 (His标签)-PDEH100959; 沙格列汀中间体(INTERMEDIATE OF SAXAGLIPTIN); N-2 (1S,3S,5S)-3-(氨基羰基)-2-氮杂双环[3.1.0]己烷-2-甲酸叔丁酯; 1S,3S,5S)-3-(氨基羰基)-2-氮杂双环[3.1.0]己烷-2-甲酸叔丁酯,沙格列汀中间体; 重组人 Glypican-3/GPC3/OCI5 (C-Fc)-PKSH033892; (1S,3S,5S)-3-(氨基羰基)-2-氮杂双环[3.1.0]己烷-2-甲; (1S,3S,5S)-2-BOC-2-氮杂二环[3.1.0]己烷-3-甲酰胺; 沙格列汀中间体-(1S,3S,5S)-3-(氨基羰基)-2-氮杂双环[3.1.0]己烷-2-甲酸叔丁酯; SGB沙格列汀中间体; (1S,3S,5S)-3-氨基羟基-2-氮杂双环[3,1,0]己烷-2-甲酸叔丁酯; 重组人 Glypican-3/GPC3/OCI5 (C-6His-Avi) Biotinylated-PKSH033852; 沙克列汀中间体 INT2; (1S,3S,5S)-3-氨基甲酰-2-氮杂双环[3.1.0]己烷-2-甲酸叔丁酯; (1S,3S,5S)-3-(氨基羰基)-2-氮杂双环[3.1.0]己烷-2-甲酸叔丁酯沙格列汀中间体3; GPC3 多克隆抗体-E-AB-53438; 沙格列汀杂质 40; 沙格列汀原中间体B; 重组人 Glypican 3/GPC3蛋白 (His标签)-PKSH033664; 沙格列汀中间体; (1S,3S,5S)-3-(氨基羰基)-2-氮杂双环[3.1.0]己烷-2-甲酸; (1S,3S,5S)-3-(氨基甲酰基)-2-氮杂双环[3.1.0]己烷-2-甲酸叔丁酯; 1S,3S,5S)-3-(氨基羰基)-2-氮杂双环[3.1.0]己烷-2-甲酸叔丁酯
• 英文别名: N-Boc-cis-4,5-Methano-L-prolinamide; UNQ873; N-Boc-L-cis-4,5-MethanoprolineaMide; Saxagliptin Impurity 40; 1,1-Dimethylethyl (1S,3S,5S)-3-(aminocbonyl)-2-azabicyclo[3.1.0]hexane-2-cboxylate; (1S,3S,5S)-3-(Aminocbonyl)-2-Azabicyclo[3.1.0]Hexane-2-Cboxylic Acid Tert-Butyl Ester / Saxagliptin Intermediate; (1S,3S,5S)-3-(AMinocbonyl)-2-azabicyclo[3.1.0]hexane-2-cboxylic acid; T35 DNTJ DVOX1&1&1 EVZ &&(1S,3S,5S)- Form; (1S,3S,5S)-tert-butyl 3-cbaMoyl-2-azabicyclo[3.1.0]hexane-2-cboxylate; (1S,3S,5S)-3-(AMinocbonyl)-2-azabicylo[3.1.0]hexane-2-cboxylic acid tert-butyl ester; Sacubitril Impurity 93; (1S,3S,5S)-3-(Aminocbonyl)-2-azabicyclo[3.1.0]hexane-2-cboxylic acid tert-butyl ester(For export only); SAXAGLIPTIN CAS 3611-8 INTERMEDIATES; tert-Butyl (1S,3S,5S)-3-(aminocbonyl)-2-azabicyclo[3.1.0]hexan-2-cboxylate; PRO1891; SGBS1; (1S,3S,5S)-3-Aminocbonyl-2-Azabicyclo[3.1.0]Hexane-2-Cboxylicacid,1,1-Dimethylethyl Ester; (1S,3S,5S)-3-(Aminocbonyl)-2-azabicyclo[3.1.0]hexane-2-cboxylic acid tert-butyl ester; ABHB (1S,3S,5S)-tert-butyl 3-cbamoyl-2-aza-bicyclo[3.1.0]hexane-2-cboxylate; (1S,3S,5S)-2-Boc-2-azabicyclo-[3.1.0]hexane-3-cboxamide; (1S,3S,5S)-2-(tert-butyl)-2-azabicyclo[3.1.0]hexane-3-cboxamide; C20orf153; (1S,3S,5S)-3-(AMINOCBONYL)-2-AZABICYCLO[3.1.0]HEXANE-2-CBOXYLIC ACID TERT-BUTYL ESTER1S; OCI-5; (1S,3S,5S)-3-(Aminocbonyl)-2-azabicyclo[3.1.0]hexane-2-c; (1S,3S,5S)-3-(Aminocbonyl)-2-azabicyclo[3.1.0]hexane-2-cboxylic acidd tert-butyl ester; tert-Butyl 3-cbamoyl-2-azabicyclo[3.1.0]hexane-2-cboxylate; (1S, 3S, 5S) -3- (aminocbonyl) -2-azabicyclic - [3.1.0] hexane-2-cboxylic acid tert butyl ester; (1S,3S,5S)-3-cbamoyl-2-azabicyclo[3.1.0]hexane-2-cboxylate tert-butyl ester; 2-Azabicyclo[3.1.0]hexane-2-cboxylic acid, 3-(aminocbonyl)-, 1,1-dimethylethyl ester, (1S,3S,5S); （C11H18N2O3，226.27）; tert-butyl(1S,3S,5S)-3-cbamoyl-2-azabicyclo[3.1.0]hexane-2-cboxylate; (1S,3S,5S)-3-(Aminocbonyl)-2-azabicyclo[3.1.0]hexane-2-cboxylic acid tert-butyl ester ISO 9001：2015 REACH; 1,1-Dimethylethyl (1S,3S,5S)-3-(aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate; Saxagliptin INT 2; MXR7; 2-Methyl-2-propanyl (1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate; (1S,3S,5S)-2-Boc-2-azabicyclo[3.1.0]hexane-3-cboxamide; (1S, 3S, 5S) -3- (amino-carbonyl) -2-azabicyclic [3.1.0] hexane-2-tert-butyl cboxylate; (Aminocbonyl)-2-azabicyclo[3.1.0]hexane-2-cboxylic acid tert-butyl ester; tert-butyl (1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate; EOS-60426; (1S,3S,5S)-3-(AMinocbonyl)-2-azabicyclo[3.1.0]hexane-2-cboxylic acid tert-butyl este; C11H18N2O3 (1S,3S,5S)-3-(Aminocbonyl)-2-azabicyclo[3.1.0]hexane-2-cboxylic acid tert-butyl ester 361-7; Saxagliptin int

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 388.9±21.0 °C at 760 mmHg
• 分子式: C₁₁H₁₈N₂O₃
• 分子量: 226.272
• 闪点: 189.0±22.1 °C
• 精确质量: 226.131744
• PSA: 72.63000
• LogP: -0.53
• 外观性状: 固体
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.538
• 储存条件: 2-8°C，干燥

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

合成路线

197142-36-2 ~82% 361440-67-7

文献：ALANTOS PHARMACEUTICALS, INC. Patent: WO2006/116157 A2, 2006 ; Location in patent: Page/Page column 114-116 ; WO 2006/116157 A2

709031-38-9 75-11-6 ~53% 361440-67-7

文献：Sharma, Padam N.; Galvin, Gabriel M.; Boettger, Susan D.; Racha, Saibaba; Zhu, Jingyang; Melton, Jack; Mudryk, Boguslaw M. Patent: US2006/35954 A1, 2006 ; Location in patent: Page/Page column 6-7 ;

24424-99-5 ~% 361440-67-7

文献：Bioorganic and Medicinal Chemistry, , vol. 22, # 4 p. 1383 - 1393

194594-23-5 ~% 361440-67-7

文献：Bioorganic and Medicinal Chemistry, , vol. 22, # 4 p. 1383 - 1393

144978-35-8 ~% 361440-67-7

文献：Bioorganic and Medicinal Chemistry, , vol. 22, # 4 p. 1383 - 1393

7149-65-7 ~% 361440-67-7

文献：Bioorganic and Medicinal Chemistry, , vol. 22, # 4 p. 1383 - 1393

178172-26-4 ~% 361440-67-7

文献：Bioorganic and Medicinal Chemistry, , vol. 22, # 4 p. 1383 - 1393

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%