300-76-5

300-76-5结构式

常用中文名：二溴磷
常用英文名：Naled
CAS号：300-76-5
分子式：C₄H₇Br₂Cl₂O₄P
分子量：380.784
相关类别：化学农药原药杀虫剂有机氯杀虫剂
发布时间：2018-02-21 08:00:00
更新时间：2024-01-11 15:14:23
Naled is an organophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.

中文名	二溴磷
英文名	naled
中文别名	万丰灵 O,O'-二甲基-1,2-二溴-2,2-二氯乙基磷酸盐 1,2-二溴-2,2,-二氯乙基二甲基磷酸酯二溴敌敌畏 1,2-二溴-2,2-二氯乙基二甲基磷酸酯
英文别名	Naled BRP EINECS 206-098-3 1,2-Dibromo-2,2-dichloroethyl dimethyl phosphate (1,2-Dibromo-2,2-dichloroethyl) dimethyl phosphate,Bromchlophos,Naled Dibrom 1,2-dibromo-2,2-dichloro-ethyl dimethyl phosphate (RS)-1,2-dibromo-2,2-dichloroethyl dimethyl phosphate Arthodibrom Phosphoric acid, 1,2-dibromo-2,2-dichloroethyl dimethyl ester MFCD00053227 Ortho-Dibrom rac-(1R)-1,2-dibromo-2,2-dichloroethyl dimethyl phosphate Orthodibromo phosphoric acid 1,2-dibromo-2,2-dichloro-ethyl ester dimethyl ester Dibromfos fosforan Phosphoric acid 1,2-dibromo-2,2-dichloroethyl dimethyl ester Fosbrom BROMCHLOPHOS Bromex (1,2-dibromo-2,2-dichloroethyl) dimethyl phosphate

密度	2.0±0.1 g/cm3
沸点	273.8±40.0 °C at 760 mmHg
熔点	26.5-27.5ºC
分子式	C₄H₇Br₂Cl₂O₄P
分子量	380.784
闪点	119.4±27.3 °C
精确质量	377.782562
PSA	54.57000
LogP	1.86
外观性状	无色至黄色液体或白色晶体,带有辛辣气味
蒸汽压	0.0±0.5 mmHg at 25°C
折射率	1.529
储存条件	储存注意事项储存于阴凉、通风的库房。远离火种、热源、包装密封。应与还原剂、碱类、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。
稳定性	1.稳定性稳定 2.禁配物还原剂、碱类 3.避免接触的条件受热 4.聚合危害不聚合 5.分解产物氯化氢、溴化氢、氧化磷
分子结构	1、摩尔折射率：57.77 2、摩尔体积（cm³/mol）：187.3 3、等张比容（90.2K）：496.0 4、表面张力（dyne/cm）：49.1 5、极化率（10-24cm3）：22.90
计算化学	1.疏水参数计算参考值（XlogP）:2.5 2.氢键供体数量:0 3.氢键受体数量:4 4.可旋转化学键数量:5 5.互变异构体数量:无 6.拓扑分子极性表面积44.8 7.重原子数量:13 8.表面电荷:0 9.复杂度:206 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:1 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：白色结晶固体或无色粘稠状液体，微有臭味。 2.熔点（℃）：26.5~27.5 3.沸点（℃）：110（0.066kPa） 4.相对密度（水=1）：1.96 5.饱和蒸气压（kPa）：0.066（110℃） 6.辛醇/水分配系数：1.38 7.闪点（℃）：＞61 8.溶解性：不溶于水，易溶于芳烃，不溶于脂肪。

国标编号:	61874
ＣＡＳ:	300-76-5
中文名称:	二溴磷
英文名称:	Dibrom
别名:	二溴灵；二溴敌敌畏；O,O-二甲基-1,2-二溴-2,2-二氯代乙基磷酸酯；Bromex
分子式:	C₄H₇O₄PBr₂Cl2
分子量:	380.80
熔点:	26.5～27.5℃ 沸点：
密度:	1.96
蒸汽压:	110℃
溶解性:	不溶于水，易溶于芳烃，不溶于脂肪，能溶于丙酮、丙二
稳定性:	稳定
外观与性状:	室温下为白色结晶固体，高温下为无色粘稠油状液体，微有臭味
危险标记:	14(有毒品)
用途:	为残效期短的杀虫剂

2.对环境的影响:
一、健康危害
侵入途径：吸入、食入、经皮吸收。
健康危害：抑制胆碱酯酶，引起神经生理功能紊乱。中毒症状有头晕、无力、视物模糊、恶性循环心、呕吐、瞳孔缩小等。严重者出现肺水肿、昏迷等。
二、毒理学资料及环境行为

急性毒性：LD ₅₀108mg/kg(大鼠经口)；300mg/kg(兔经皮)
致突变性：微生物致突变：鼠伤害沙门氏菌500nmol/皿；大肠杆菌20ul/皿。姊妹染色交换：人淋巴细胞 10nmol/L。
致癌性：IARC致癌性评论：动物阳性。
危险特性：遇明火、高热可燃。受热分解，放出有毒气体。
燃烧(分解)产物：氯化氢、溴化氢、氧化磷。

3.现场应急监测方法:　

4.实验室监测方法:
气相色谱法《固体废弃物试验分析评价手册》中国环境监测总站等译
气相色谱法(农作物)《农药残留量气相色谱法》国家商检局编

5.环境标准:

前苏联	车间空气中有害物质的最高容许浓度	0.5mg/m³
联合国规划署(1974)	保护水生生物淡水中农药的最大允许浓度	0.004μg/L
美国(1981年)	食物和饮料中最高残留限值	0.05～10.0mg/kg(特定动、植物粗制品)

6.应急处理处置方法:
一、泄漏应急处理
迅速撤离泄漏污染区，严格限制出入。切断火源，不要直接接触泄漏物。小量泄漏：用砂土或其它不燃材料吸附或吸收。大量泄漏：构筑围堤或挖坑收容；用泡沫覆盖，降低蒸气灾害。用泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。若是固体，用洁净的铲子收集于干燥、洁净、有盖的容器中。若大量泄漏，收集回收或运至废物处理场所处置。
二、防护措施
呼吸系统防护：生产操作或农业使用时，佩戴过滤式防毒面具(半面罩)。空气中浓度较高时，必须佩戴自给式呼吸器。
眼睛防护：戴化学安全防护眼镜。
身体防护：穿聚乙烯防毒服。
手防护：戴氯丁橡胶手套。
其它：皮肤防护也可采用塑料薄膜和涂皂面布相结合的方法。工作毕，淋浴更衣。注意个人清洁卫生。
三、急救措施
皮肤接触：立即脱去被污染的衣着，用肥皂水及流动清水彻底冲洗污染的皮肤、头发、指甲等。就医。
眼睛接触：提起眼睑，用流动清水或生理盐水冲洗。就医。
吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。
食入：饮足量温水，催吐，用清水或2%～5%碳酸氢钠溶液洗胃。就医。
灭火方法：消防人员须佩戴防毒面具、穿全身消防服。用干粉、砂土、泡沫与二氧化碳灭火器灭火。

毒理学数据:

1.急性毒性

LD50：430mg/kg（大鼠经口）；1100mg/kg（兔经皮）

2.刺激性家兔经皮：500mg（24h），重度刺激。

3.亚急性与慢性毒性连续给兔皮下注射乳剂1月，0.1LD50引起重度中毒，ChE活性显著下降，死亡率达60%。

4.致突变性微生物致突变：鼠伤寒沙门菌50μg/皿。微生物致突变：枯草菌50μg/皿。

生态学数据:

1.生态毒性

LC50：0.127mg/L（96h）（山鳟，静态）；0.132mg/L（96h）（虹鳟鱼）；3.3mg/L（96h）（黑头呆鱼，静态）；0.18mg/L（96h）（蓝鳃太阳鱼）

EC50：0.3ppb（48h）（水蚤，静态）；1.5ppb（48h）（水蚤，动态）

2.生物降解性暂无资料

3.非生物降解性空气中，当羟基自由基浓度为5.00×10⁵个/cm³时，降解半衰期为2.5d（理论）。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TB9450000

CHEMICAL NAME :: Phosphoric acid, 1,2-dibromo-2,2-dichloroethyl dimethyl ester

CAS REGISTRY NUMBER :: 300-76-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 43

MOLECULAR FORMULA :: C4-H7-Br2-Cl2-O4-P

MOLECULAR WEIGHT :: 380.80

WISWESSER LINE NOTATION :: GXGEYEOPO&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human - man

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 92 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 222 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1500 mg/m3/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 52 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1350 mg/kg/9W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - body temperature decrease Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Bacillus subtilis

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 29,268,1981 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 3 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 3 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,73,1971 OSHA PEL (Gen Indu):8H TWA 3 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 3 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 3 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 3 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 3 mg/m3;Skin JAN 1993 OEL-AUSTRIA:TWA 3 mg/m3 JAN 1993 OEL-BELGIUM:TWA 3 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 3 mg/m3 JAN 1993 OEL-FINLAND:TWA 3 mg/m3;STEL 6 mg/m3 JAN 1993 OEL-FRANCE:TWA 3 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 3 mg/m3;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 3 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 3 mg/m3 JAN 1993 OEL-THAILAND:TWA 3 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 3 mg/m3;STEL 6 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO THE CHEMICAL-air:10H TWA 3 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 26420 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 16 (estimated)

符号	GHS06, GHS09
信号词	Danger
危害声明	H301-H312-H315-H319-H400
警示性声明	P273-P301 + P310 + P330-P302 + P352 + P312-P305 + P351 + P338-P337 + P313-P391
个人防护装备	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
危害码 (欧洲)	Xn,N,T
风险声明 (欧洲)	R21/22
安全声明 (欧洲)	36/37-61
危险品运输编码	3018
WGK德国	3
RTECS号	TB9450000
包装等级	I
海关编码	2919900090

海关编码	2919900090
中文概述	HS:2919900090 其他磷酸酯及其盐（包括乳磷酸盐）（包括它们的卤化，磺化，硝化和亚硝化衍生物）增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	2919900090 other phosphoric esters and their salts, including lactophosphates; their halogenated, sulphonated, nitrated or nitrosated derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

300-76-5	16230-28-7
3344-70-5	24554-43-6
1000310-63-3	683-68-1
594-18-3	106-93-4
10031-24-0	602-92-6