55-52-7

• 常用中文名：苯异丙肼
• 常用英文名：Pheniprazine
• CAS号：55-52-7
• 分子式：C₉H₁₄N₂
• 分子量：150.22100
• 相关类别： 信号通路 神经信号通路 单胺氧化酶
• 发布时间：2018-06-01 08:00:00
• 更新时间：2025-08-24 18:45:18
• 苯丙嗪是一种有效的单胺氧化酶长效抑制剂。非尼哌嗪有研究抑郁症的潜力[1]。

名称

• 中文名: 苯异丙肼
• 英文名: 1-phenylpropan-2-ylhydrazine
• 中文别名: 1-(1-苯基丙烷-2-基)肼
• 英文别名: Dicatron; Phenizine; 2-Hydrazinopropylbenzene; Pheniprazine; Catron; fenizin; Fenilisopropilidrazina

物化性质

• 密度: 0.99g/cm3
• 沸点: 287.1ºC at 760mmHg
• 分子式: C₉H₁₄N₂
• 分子量: 150.22100
• 闪点: 148ºC
• 精确质量: 150.11600
• PSA: 38.05000
• LogP: 2.17210
• 折射率: 1.539

生物活性

• 描述: 苯丙嗪是一种有效的单胺氧化酶长效抑制剂。非尼哌嗪有研究抑郁症的潜力[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> 单胺氧化酶
  研究领域 >> 神经疾病
• 靶点:

  monoamine oxidase[1]

• 参考文献:

  [1]. HORITA A. beta-Phenylisopropylhydrazine, a potent and long acting monoamine oxidase inhibitor. J Pharmacol Exp Ther.

  [2]. Stein, Larry, et al. Accelerated recovery from reserpine depression by monoamine oxidase inhibitors.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MV7350000 CHEMICAL NAME : Hydrazine, (alpha-methylphenethyl)- CAS REGISTRY NUMBER : 55-52-7 LAST UPDATED : 199706 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C9-H14-N2 MOLECULAR WEIGHT : 150.25 WISWESSER LINE NOTATION : ZMY1&1R HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - man DOSE/DURATION : 117 mg/kg/2.5Y TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - effect, not otherwise specified TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 34 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 45 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 44 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 121 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 48 mg/kg TOXIC EFFECTS : Behavioral - anticonvulsant TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 95 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 12100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 10 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 5,343,1968

安全

• 海关编码: 2928000090

合成路线

5171-99-3 ~% 55-52-7

文献：Journal of the American Chemical Society, , vol. 81, p. 2805,2810, 2813

103-79-7 ~% 55-52-7

文献：Journal of Medicinal and Pharmaceutical Chemistry, , vol. 5, # 2 p. 221 - 230

100-39-0 ~% 55-52-7

文献：Journal of the Chemical Society, Chemical Communications, , # 2 p. 176 - 178

2114-39-8 ~% 55-52-7

文献：Journal of Medicinal Chemistry, , vol. 54, # 8 p. 2610 - 2626

19852-13-2 ~% 55-52-7

文献：J. Gen. Chem. USSR (Engl. Transl.), , vol. 30, p. 2754 - 2756,2736 - 2738

637-50-3 ~% 55-52-7

文献：Chemische Berichte, , vol. 98, p. 904 - 911

海关

海关编码	2928000090
中文概述	2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%