220352-36-3

• 常用中文名：(1R,2S)-rel-2-(3,4-二氟苯基)环丙基甲酸
• 常用英文名：(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid
• CAS号：220352-36-3
• 分子式：C₁₀H₈F₂O₂
• 分子量：198.166
• 发布时间：2017-01-11 15:47:24
• 更新时间：2025-08-25 14:27:07

名称

• 中文名: (1R,2S)-rel-2-(3,4-二氟苯基)环丙基甲酸
• 英文名: (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid
• 英文别名: trans-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid; trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid; (1R,2R)-trans-2-(3,4-difluorophenyl)-1-cyclopropanecarboxylic acid; (1R-trans)-2-(3,4-difluorophenyl)-cyclopropanecarboxylic acid; Cyclopropanecarboxylic acid, 2-(3,4-difluorophenyl)-, (1R,2R)-; (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid; (1R,2R)-2-(3,4-difluorophenyl)-1-cyclopropanecarboxylic acid

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 308.1±42.0 °C at 760 mmHg
• 分子式: C₁₀H₈F₂O₂
• 分子量: 198.166
• 闪点: 140.1±27.9 °C
• 精确质量: 198.049240
• PSA: 37.30000
• LogP: 1.74
• 外观性状: 棕黄色结晶粉末
• 蒸汽压: 0.0±0.7 mmHg at 25°C
• 折射率: 1.556
• 储存条件: 室温，干燥，密封，惰性气体

安全

• 危害码 (欧洲): Xi

合成路线

1006376-61-9 ~96% 220352-36-3

文献：ASTRAZENECA AB Patent: WO2008/18823 A1, 2008 ; Location in patent: Page/Page column 30-31 ; WO 2008/018823 A1

34036-07-2 ~% 220352-36-3

文献：ACTAVIS GROUP PTC EHF; Khile, Anil Shahaji; Nair, Vignesh; Trivedi, Nikhil; Pradhan, Nitin Sharadchandra Patent: US2013/165696 A1, 2013 ;

405-03-8 ~% 220352-36-3

文献：ACTAVIS GROUP PTC EHF; Khile, Anil Shahaji; Nair, Vignesh; Trivedi, Nikhil; Pradhan, Nitin Sharadchandra Patent: US2013/165696 A1, 2013 ;

112897-97-9 ~% 220352-36-3

文献：AUSPEX PHARMACEUTICALS, INC.; RAO, Tadimeti; ZHANG, Chengzhi Patent: WO2011/17108 A2, 2011 ; WO 2011/017108 A2

1043546-64-0 ~% 220352-36-3

文献：AUSPEX PHARMACEUTICALS, INC.; RAO, Tadimeti; ZHANG, Chengzhi Patent: WO2011/17108 A2, 2011 ; WO 2011/017108 A2

1006376-60-8 ~% 220352-36-3

文献：Zhang, Hao; Liu, Jun; Zhang, Luyong; Kong, Lingyi; Yao, Hequan; Sun, Hongbin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3598 - 3602

1006376-63-1 ~% 220352-36-3

文献：Zhang, Hao; Liu, Jun; Zhang, Luyong; Kong, Lingyi; Yao, Hequan; Sun, Hongbin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3598 - 3602

367-11-3 ~% 220352-36-3

文献：Zhang, Hao; Liu, Jun; Zhang, Luyong; Kong, Lingyi; Yao, Hequan; Sun, Hongbin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3598 - 3602

51336-95-9 ~% 220352-36-3

文献：Zhang, Hao; Liu, Jun; Zhang, Luyong; Kong, Lingyi; Yao, Hequan; Sun, Hongbin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3598 - 3602

上下游产品

上游产品  9
1006376-61-9 34036-07-2 405-03-8 112897-97-9
1043546-64-0 1006376-60-8 1006376-63-1 367-11-3
51336-95-9
下游产品  3
274693-27-5 1402222-66-5 1006376-62-0