99614-01-4

• 常用中文名：Ondansetron HCl
• 常用英文名：Ondansetron Hydrochloride
• CAS号：99614-01-4
• 分子式：C₁₈H₂₀ClN₃O
• 分子量：329.824
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) 5-HT Receptor 拮抗剂
• 发布时间：2018-06-13 19:30:14
• 更新时间：2024-01-02 11:49:50
• Ondansetron盐酸盐是5-HT3受体拮抗剂，可作为化疗后止吐剂。

名称

• 中文名: 盐酸枢复宁
• 英文名: ondansetron hydrochloride
• 中文别名: 盐酸昂丹司琼; 帕罗西汀杂质A
• 英文别名: UNII:2999F27MAD; (R)-Ondansetron Hydrochloride Dihydrate; 4H-CARBAZOL-4-ONE,1,2,3,9-TETRAHYDRO-9-METHYL-3-[(2-METHYL-1H-IMIDAZOL-1-YL)METHYL]-,HYDROCHLORIDE (1:1); 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one; LSUREMONOETHANOLAMID; Ondansetron HCl; 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride; OEA,oleoylethanolamide; N-(Hydroxyethyl)oleamide; 9-Methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride; [3H]-Oleoylethanolamide; oleic acid ethanolamide; ONDANSETRON HCL DIHYDRATE; 9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4h-carbazol-4-onhydrochlorid; Ondansetron HCl (Zofran); 4H-carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-, monohydrochloride; oleic monoethanolamide; Ondansetron (hydrochloride); ONDANSETRONHYDROCHLORIDE; ONDANSETRON HCL DIHYDRATE IMP. E (EP): 1H-IMIDAZOLE, CRM STANDARD; Ondansetron hydrochloride (Zofran); oleic acid-N-monoethanolamide; N-(2-Hydroxyethyl)oleamide; OEA; Oleoylethanolamide; [3H]-Ondansetron hydrochloride; 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-, hydrochloride (1:1); ODANSETRON HYDROCHLORIDE DIHYDRATE; Ondansetron Hydrochloride; Oleyl monoethanolamide; OLEAMIDE MEA; 9-méthyl-3-[(2-méthyl-1H-imidazol-1-yl)méthyl]-1,2,3,9-tétrahydro-4H-carbazol-4-one chlorhydrate; Oleoylmonoethanolamide; 9-Methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride (1:1)

物化性质

• 密度: 1.27g/cm3
• 沸点: 546ºC at 760mmHg
• 熔点: 178.5-179.5ºC
• 分子式: C₁₈H₂₀ClN₃O
• 分子量: 329.824
• 闪点: 284ºC
• 精确质量: 329.129486
• PSA: 39.82000
• LogP: 3.93050
• 外观性状: 白色粉末
• 储存条件: −20°C
• 水溶解性: H2O: >5 mg/mL

生物活性

• 描述: Ondansetron盐酸盐是5-HT3受体拮抗剂,可作为化疗后止吐剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Brown AM, et al. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol. 1998 Mar 15;507 ( Pt 3):653-65.

  [2]. Barann M, et al. Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep;362(3):255-65.

  [3]. Wildeboer KM, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 1;1300:41-50.

  [4]. Khedhaier A, et al. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov;20(6):1103-16.

  [5]. Umathe SN, et al. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol. 2009 Feb;20(1):78-83.

  [6]. Doggrell SA, et al. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia. Expert Opin Drug Saf. 2013 May;12(3):421-31.

安全

• 危害码 (欧洲): T: Toxic;
• 风险声明 (欧洲): R25
• 安全声明 (欧洲): 45-37/39-26
• 危险品运输编码: UN 2811 6
• WGK德国: 3
• RTECS号: FE6375500
• 包装等级: II
• 危险类别: 6.1(a)
• 海关编码: 29339900

合成路线

99614-02-5 ~90% 99614-01-4

文献：WO2005/37822 A1, ; Page/Page column 12 ;

693-98-1 27387-31-1 51-80-9 ~78% 99614-01-4

文献：WO2005/37822 A1, ; Page/Page column 12 ;

99614-60-5 ~93% 99614-01-4

文献：YUHAN CORPORATION Patent:   WO2005/37822 A1, 2005 ; Location in patent: Page/Page column 12 ;

上下游产品

上游产品  4
99614-02-5 27387-31-1 51-80-9 99614-60-5
下游产品  2
99614-02-5 99614-60-5