143540-05-0

• 常用中文名：1,4-双(Boc)-2-哌嗪甲醇
• 常用英文名：2-(Hydroxymethyl)-1,4-piperazinedicarboxylic acid 1,4-bis(tert-butyl) ester
• CAS号：143540-05-0
• 分子式：C₁₅H₂₈N₂O₅
• 分子量：316.39300
• 发布时间：2018-12-22 22:35:31
• 更新时间：2024-01-09 11:48:35

名称

• 中文名: 2-(羟甲基)-1,4-哌嗪二羧酸二叔丁酯
• 英文名: ditert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate
• 中文别名: 2-(羟基甲基)哌嗪-1,4-二羧酸二叔丁酯; 1,4-双(Boc)-2-哌嗪甲醇
• 英文别名: 2-hydroxymethylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester; 1,4-Piperazinedicarboxylic acid, 2-(hydroxymethyl)-, 1,4-bis(1,1-dimethylethyl) ester

物化性质

• 分子式: C₁₅H₂₈N₂O₅
• 分子量: 316.39300
• 精确质量: 316.20000
• PSA: 79.31000
• LogP: 1.71090
• 储存条件: 室温，干燥

安全

• 海关编码: 2933599090

合成路线

543-27-1 181955-79-3 ~81% 143540-05-0

文献：Matsumoto, Takahiro; Kamo, Izumi; Nomura, Izumi Patent: US2009/318412 A1, 2009 ; Location in patent: Page/Page column 34 ; US 20090318412 A1

171504-98-6 ~% 143540-05-0

文献：AGIOS PHARMACEUTICALS, INC.; CAO, Sheldon; POPOVICI-MULLER, Janeta; SALITURO, Francesco G.; SAUNDERS, Jeffrey; TAN, Xuefei; TRAVINS, Jeremy; YAN, Shunqi; YE, Zhixiong Patent: WO2012/171506 A1, 2012 ; Location in patent: Page/Page column 113 ; WO 2012/171506 A1

181955-79-3 ~85% 143540-05-0

文献：Clark, Roger B.; Elbaum, Daniel Tetrahedron, 2007 , vol. 63, # 14 p. 3057 - 3065

13292-87-0 181955-79-3 ~% 143540-05-0

文献：Agejas-Chicharro, Javier; Belen Bueno Melendo, Ana; Camp, Nicholas Paul; Gilmore, Jeremy; Jimenez-Aguado, Alma Maria; Lamas-Peteira, Carlos; Marcos-Llorente, Alicia; Mazanetz, Michael Philip; Montero Salgado, Carlos; Timms, Graham Henry; Williams, Andrew Caerwyn Patent: US2004/122001 A1, 2004 ; US 20040122001 A1

24424-99-5 ~% 143540-05-0

文献：AGIOS PHARMACEUTICALS, INC.; CAO, Sheldon; POPOVICI-MULLER, Janeta; SALITURO, Francesco G.; SAUNDERS, Jeffrey; TAN, Xuefei; TRAVINS, Jeremy; YAN, Shunqi; YE, Zhixiong Patent: WO2012/171506 A1, 2012 ; WO 2012/171506 A1

28795-50-8 24424-99-5 ~% 143540-05-0

文献：Wacker, Dean A; Santella 3rd., Joseph B; Gardner, Daniel S; Varnes, Jeffrey G; Estrella, Melissa; DeLucca, George V; Ko, Soo S; Tanabe, Keiichi; Watson, Paul S; Welch, Patricia K; Covington, Maryanne; Stowell, Nicole C; Wadman, Eric A; Davies, Paul; Solomon, Kimberly A; Newton, Robert C; Trainor, George L; Friedman, Steven M; Decicco, Carl P; Duncia, John V Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 13 p. 1785 - 1789

上下游产品

上游产品  6
543-27-1 181955-79-3 171504-98-6 13292-87-0
24424-99-5 28795-50-8
下游产品  4
502649-29-8 935544-47-1 317365-33-6 301673-16-5

海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%