2-(Hydroxymethyl)-1,4-piperazinedicarboxylic acid 1,4-bis(tert-butyl) ester

Modify Date: 2024-01-09 11:48:35

2-(Hydroxymethyl)-1,4-piperazinedicarboxylic acid 1,4-bis(tert-butyl) ester Structure
2-(Hydroxymethyl)-1,4-piperazinedicarboxylic acid 1,4-bis(tert-butyl) ester structure
Common Name 2-(Hydroxymethyl)-1,4-piperazinedicarboxylic acid 1,4-bis(tert-butyl) ester
CAS Number 143540-05-0 Molecular Weight 316.39300
Density N/A Boiling Point N/A
Molecular Formula C15H28N2O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Names

Name ditert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate
Synonym More Synonyms

 Chemical & Physical Properties

Molecular Formula C15H28N2O5
Molecular Weight 316.39300
Exact Mass 316.20000
PSA 79.31000
LogP 1.71090

 Safety Information

HS Code 2933599090

 Synthetic Route

~81%

2-(Hydroxymethyl)-1,4-piperazinedicarboxylic acid 1,4-bis(tert-butyl) ester Structure

2-(Hydroxymethy...

CAS#:143540-05-0

Literature: Matsumoto, Takahiro; Kamo, Izumi; Nomura, Izumi Patent: US2009/318412 A1, 2009 ; Location in patent: Page/Page column 34 ; US 20090318412 A1

~%

2-(Hydroxymethyl)-1,4-piperazinedicarboxylic acid 1,4-bis(tert-butyl) ester Structure

2-(Hydroxymethy...

CAS#:143540-05-0

Literature: AGIOS PHARMACEUTICALS, INC.; CAO, Sheldon; POPOVICI-MULLER, Janeta; SALITURO, Francesco G.; SAUNDERS, Jeffrey; TAN, Xuefei; TRAVINS, Jeremy; YAN, Shunqi; YE, Zhixiong Patent: WO2012/171506 A1, 2012 ; Location in patent: Page/Page column 113 ; WO 2012/171506 A1

~85%

2-(Hydroxymethyl)-1,4-piperazinedicarboxylic acid 1,4-bis(tert-butyl) ester Structure

2-(Hydroxymethy...

CAS#:143540-05-0

Literature: Clark, Roger B.; Elbaum, Daniel Tetrahedron, 2007 , vol. 63, # 14 p. 3057 - 3065

~%

2-(Hydroxymethyl)-1,4-piperazinedicarboxylic acid 1,4-bis(tert-butyl) ester Structure

2-(Hydroxymethy...

CAS#:143540-05-0

Literature: Agejas-Chicharro, Javier; Belen Bueno Melendo, Ana; Camp, Nicholas Paul; Gilmore, Jeremy; Jimenez-Aguado, Alma Maria; Lamas-Peteira, Carlos; Marcos-Llorente, Alicia; Mazanetz, Michael Philip; Montero Salgado, Carlos; Timms, Graham Henry; Williams, Andrew Caerwyn Patent: US2004/122001 A1, 2004 ; US 20040122001 A1

~%

2-(Hydroxymethyl)-1,4-piperazinedicarboxylic acid 1,4-bis(tert-butyl) ester Structure

2-(Hydroxymethy...

CAS#:143540-05-0

Literature: AGIOS PHARMACEUTICALS, INC.; CAO, Sheldon; POPOVICI-MULLER, Janeta; SALITURO, Francesco G.; SAUNDERS, Jeffrey; TAN, Xuefei; TRAVINS, Jeremy; YAN, Shunqi; YE, Zhixiong Patent: WO2012/171506 A1, 2012 ; WO 2012/171506 A1

~%

2-(Hydroxymethyl)-1,4-piperazinedicarboxylic acid 1,4-bis(tert-butyl) ester Structure

2-(Hydroxymethy...

CAS#:143540-05-0

Literature: Wacker, Dean A; Santella 3rd., Joseph B; Gardner, Daniel S; Varnes, Jeffrey G; Estrella, Melissa; DeLucca, George V; Ko, Soo S; Tanabe, Keiichi; Watson, Paul S; Welch, Patricia K; Covington, Maryanne; Stowell, Nicole C; Wadman, Eric A; Davies, Paul; Solomon, Kimberly A; Newton, Robert C; Trainor, George L; Friedman, Steven M; Decicco, Carl P; Duncia, John V Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 13 p. 1785 - 1789

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-hydroxymethylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester
1,4-Piperazinedicarboxylic acid, 2-(hydroxymethyl)-, 1,4-bis(1,1-dimethylethyl) ester
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