131926-98-2

• 常用中文名：AG1908
• 常用英文名：5-Hydroxylansoprazole
• CAS号：131926-98-2
• 分子式：C₁₆H₁₄F₃N₃O₃S
• 分子量：385.36100
• 相关类别： 信号通路 跨膜转运 质子泵
• 发布时间：2018-04-07 08:00:00
• 更新时间：2026-07-02 07:07:28
• 5-Hydroxylansoprazole (AG1908) 是血浆中 Lansoprazole 的活性代谢产物。Lansoprazole 由 CYP2C19 代谢形成 5-Hydroxylansoprazole。Lansoprazole 是一种胃质子泵 (proton-pump) 抑制剂,可有效治疗各种消化系统疾病。

名称

• 中文名: 5-羟基兰索拉唑
• 英文名: 5-hydroxy lansoprazole
• 中文别名: 兰索拉唑杂质 13; 5-羟基兰索拉唑杂质; 5-羟基兰素拉唑; 兰索拉唑5-羟基杂质
• 英文别名: Lansoprazole Impurity 18; 5'-hydroxylansoprazole; 5-Hydroxy LansoprazoleQ: What is 5-Hydroxy Lansoprazole Q: What is the CAS Number of 5-Hydroxy Lansoprazole Q: What is the storage condition of 5-Hydroxy Lansoprazole Q: What e the applications of 5-Hydroxy Lansoprazole; 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazol-5-ol; Lansoprazole 5-Hydroxy; 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazol-6-ol; 5-Hydroxy Lansoprazole DISCONTINUED. See H943711; 5-Hydroxy Lansoprazole; 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazol-5-ol; 2-[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methylsulfinyl]-1H-benzimidazole-5-ol; 1H-Benzimidazol-6-ol, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]; 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylsulfinyl]-5-hydroxy-1H-benzimidazole; 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-3H-benzimidazol-5-ol; 1-(1H-benzo[d]imidazol-2-yl)-2,3-dimethyl-4-(2,2,2- trifluoroethoxy)pyridin-1-ium; AG-1908; Lansoprazole 5-Hydroxy Impurity

物化性质

• 熔点: >155ºC (dec.)
• 分子式: C₁₆H₁₄F₃N₃O₃S
• 分子量: 385.36100
• 精确质量: 385.07100
• PSA: 107.31000
• LogP: 4.08650
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: 5-Hydroxylansoprazole (AG1908) 是血浆中 Lansoprazole 的活性代谢产物。Lansoprazole 由 CYP2C19 代谢形成 5-Hydroxylansoprazole。Lansoprazole 是一种胃质子泵 (proton-pump) 抑制剂,可有效治疗各种消化系统疾病。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> 跨膜转运 >> 质子泵
• 靶点:

  Proton Pump[1]

• 参考文献:

  [1]. Xu HR, et al. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol. 2010 Aug;48(8):947-52. doi: 10.3109/13880200903300220.

  [2]. Katarína Kostolanská, et al. Determination of lansoprazole, 5-hydroxylansoprazole, and lansoprazole sulfone in human plasma for CYP2C19 and CYP3A4 phenotyping. Chemical Papers. volume 73, pages2955–2963(2019).