5-Hydroxylansoprazole

Modify Date: 2024-01-03 11:51:41

5-Hydroxylansoprazole Structure
5-Hydroxylansoprazole structure
Common Name 5-Hydroxylansoprazole
CAS Number 131926-98-2 Molecular Weight 385.36100
Density N/A Boiling Point N/A
Molecular Formula C16H14F3N3O3S Melting Point >155ºC (dec.)
MSDS N/A Flash Point N/A

 Use of 5-Hydroxylansoprazole


5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole in plasma. Lansoprazole is metabolized by CYP2C19 forming 5-Hydroxylansoprazole. Lansoprazole is a gastric proton-pump inhibitor and is effective in the treatment of various peptic diseases[1][2].

 Names

Name 5-hydroxy lansoprazole
Synonym More Synonyms

 5-Hydroxylansoprazole Biological Activity

Description 5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole in plasma. Lansoprazole is metabolized by CYP2C19 forming 5-Hydroxylansoprazole. Lansoprazole is a gastric proton-pump inhibitor and is effective in the treatment of various peptic diseases[1][2].
Related Catalog
Target

Proton Pump[1]

References

[1]. Xu HR, et al. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol. 2010 Aug;48(8):947-52. doi: 10.3109/13880200903300220.

[2]. Katarína Kostolanská, et al. Determination of lansoprazole, 5-hydroxylansoprazole, and lansoprazole sulfone in human plasma for CYP2C19 and CYP3A4 phenotyping. Chemical Papers. volume 73, pages2955–2963(2019).

 Chemical & Physical Properties

Melting Point >155ºC (dec.)
Molecular Formula C16H14F3N3O3S
Molecular Weight 385.36100
Exact Mass 385.07100
PSA 107.31000
LogP 4.08650

 Synonyms

2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazol-5-ol
2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylsulfinyl]-5-hydroxy-1H-benzimidazole
AG-1908
2-[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methylsulfinyl]-1H-benzimidazole-5-ol
5'-hydroxylansoprazole
Lansoprazole Impurity 18