3562-99-0

• 常用中文名：孟布酮
• 常用英文名：Menbutone
• CAS号：3562-99-0
• 分子式：C₁₅H₁₄O₄
• 分子量：258.26900
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-07-19 17:57:45
• 更新时间：2024-01-02 13:00:34
• Menbutone是氧代丁酸衍生物, 是一种利胆剂, 快速起效, 1小时内达到其最大血浆水平, 且可持续约10小时。

名称

• 中文名: 孟布酮
• 英文名: 3-(4-methoxy-1-naphthoyl)propionic acid
• 中文别名: 3-(4-甲氧基-1-萘)丙酸
• 英文别名: menbutone; ido-genabil; naftobil; epanaftol; genabil; genabilin; menbuton; Icteryl; 3-(4-Methoxy-1-Naphthoyl)Propionic Acid; fel-bis

物化性质

• 密度: 1.249 g/cm3
• 沸点: 511.5ºC at 760 mmHg
• 分子式: C₁₅H₁₄O₄
• 分子量: 258.26900
• 闪点: 196.6ºC
• 精确质量: 258.08900
• PSA: 63.60000
• LogP: 2.89590
• 折射率: 1.629
• 储存条件: 室温，干燥

生物活性

• 描述: Menbutone是氧代丁酸衍生物, 是一种利胆剂, 快速起效, 1小时内达到其最大血浆水平, 且可持续约10小时。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UF5276000 CHEMICAL NAME : Propionic acid, 3-(4-methoxy-1-naphthoyl)- CAS REGISTRY NUMBER : 3562-99-0 BEILSTEIN REFERENCE NO. : 3059815 LAST UPDATED : 199712 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C15-H14-O4 MOLECULAR WEIGHT : 258.29 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,154,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 570 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,154,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,244,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,154,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 380 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,154,1958

合成路线

108-30-5 2216-69-5 ~% 3562-99-0

文献：Helvetica Chimica Acta, , vol. 15, p. 907,914

90-15-3 ~% 3562-99-0

文献：Journal of the American Chemical Society, , vol. 73, p. 4970

10441-51-7 77-78-1 ~% 3562-99-0

文献：Journal of the American Chemical Society, , vol. 73, p. 4970

108-30-5 ~% 3562-99-0

文献：Journal of the Indian Chemical Society, , vol. 14, p. 58

108-30-5 75-15-0 7446-70-0 2216-69-5 ~% 详细

文献：Journal of the American Chemical Society, , vol. 58, p. 2314,2316 Helvetica Chimica Acta, , vol. 15, p. 907,914 Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, , vol. 5/2, p. 73,75

108-30-5 7446-70-0 630-20-6 2216-69-5 ~% 详细

文献：Journal of the American Chemical Society, , vol. 58, p. 2314,2316 Helvetica Chimica Acta, , vol. 15, p. 907,914 Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, , vol. 5/2, p. 73,75

108-30-5 7446-70-0 98-95-3 2216-69-5 ~% 详细

文献：Journal of the American Chemical Society, , vol. 58, p. 2314,2316 Helvetica Chimica Acta, , vol. 15, p. 907,914 Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, , vol. 5/2, p. 73,75

上下游产品

上游产品  9
108-30-5 2216-69-5 90-15-3 10441-51-7
77-78-1 75-15-0 7446-70-0 630-20-6
98-95-3
下游产品  5
10465-20-0 1446-34-0 10441-52-8 19817-09-5
5345-90-4