毒理学数据:
1.急性毒性 LC50:1276ppm(大鼠吸入,1h);342ppm(小鼠吸入,1h)
2.刺激性
大鼠经皮:50%(3min),重度刺激。
人经眼:50mg,重度刺激。
3.亚急性与慢性毒性 家兔吸入33~41mg/m3,平均20mg/m3,经过1~5.5个月,可出现黏膜刺激,消瘦,呼吸困难,血红蛋白减少,网织红细胞增多,部分动物死亡。
4.致突变性 DNA损伤:黑腹果蝇吸入1300ppb(6周)。性染色体缺失和不分离:黑腹果蝇吸入2900ppb。细胞遗传学分析:大鼠吸入1mg/m3,每天6h,共24d(间断性)。
5.其他 大鼠吸入最低中毒浓度(TCLo):4980μg/m3(孕1~22d),引起胎死。
生态学数据:
1.生态毒性 暂无资料
2.生物降解性 暂无资料
3.非生物降解性 暂无资料
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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MW7875000
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CHEMICAL NAME :
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Hydrofluoric acid
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CAS REGISTRY NUMBER :
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7664-39-3
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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54
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MOLECULAR FORMULA :
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F-H
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MOLECULAR WEIGHT :
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20.01
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WISWESSER LINE NOTATION :
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H F
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Human
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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100 mg/m3/1M
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - cough
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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143 mg/kg
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TOXIC EFFECTS :
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Cardiac - arrhythmias (including changes in conduction) Vascular - BP lowering not characterized in autonomic section Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Human
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DOSE/DURATION :
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50 ppm/30M
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1276 ppm/1H
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - lacrimation Behavioral - changes in motor activity (specific assay) Gastrointestinal - changes in structure or function of salivary glands
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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25 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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342 ppm/1H
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - corneal damage Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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500 mg/kg
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TOXIC EFFECTS :
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Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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1774 ppm/1H
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TOXIC EFFECTS :
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Behavioral - coma Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - other changes
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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260 mg/m3/7H
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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4327 ppm/15M
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Amphibian - frog
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DOSE/DURATION :
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112 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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300 ug/m3/24H/22W-C
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TOXIC EFFECTS :
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Behavioral - alteration of classical conditioning Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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252 ug/m3/6H/17W-I
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TOXIC EFFECTS :
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Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - monoamine oxidase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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DOSE :
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470 ug/m3/4H
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SEX/DURATION :
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female 1-22 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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DOSE :
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4980 ug/m3/4H
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SEX/DURATION :
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female 1-22 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetal death
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TYPE OF TEST :
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DNA damage
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TYPE OF TEST :
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Sex chromosome loss and nondisjunction
MUTATION DATA
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TEST SYSTEM :
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Rodent - rat
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REFERENCE :
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CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 9(1),40,1975 *** REVIEWS *** ACGIH TLV-CL 2.3 mg/m3 (3 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88. Volume(issue)/page/year: 400,5,1963 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 3 ppm (2 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,131,1971 OSHA PEL (Gen Indu):8H TWA 3 ppm CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 3 ppm (2 mg(F)/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 3 ppm (2 mg(F)/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 3 ppm (2 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 2 ppm (2 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 3 ppm (2.5 mg/m3) JAN 1993 OEL-BELGIUM:STEL 3 ppm (2.6 mg/m3) JAN 1993 OEL-DENMARK:TWA 2 ppm (1.6 mg/m3) JAN 1993 OEL-FINLAND:STEL 6 ppm;Skin JAN 1993 OEL-FRANCE:STEL 3 ppm (2.5 mg/m3) JAN 1993 OEL-GERMANY:TWA 3 ppm (2 mg/m3) JAN 1993 OEL-HUNGARY:TWA 0.5 mg/m3;STEL 1 mg/m3 JAN 1993 OEL-JAPAN:TWA 3 ppm (25 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 3 ppm (2 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 3 ppm (2 mg/m3) JAN 1993 OEL-POLAND:TWA 0.5 mg/m3 JAN 1993 OEL-RUSSIA:TWA 3 ppm (0.1 mg/m3);STEL 0.5 mg/m3 JAN 1993 OEL-SWEDEN:STEL 2 ppm (1.7 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 1.8 ppm (1.5 mg/m3);STEL 3.6 ppm (3 mg/m3) JAN 1993 OEL-TURKEY:TWA 3 ppm (2 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 3 ppm (2.5 mg/m3);STEL 6 ppm (5 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HYDROGEN FLUORIDE-air:10H TWA 3 ppm;STEL 6 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 38550 No. of Facilities: 6590 (estimated) No. of Industries: 97 No. of Occupations: 68 No. of Employees: 68886 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 38550 No. of Facilities: 11332 (estimated) No. of Industries: 96 No. of Occupations: 89 No. of Employees: 189051 (estimated) No. of Female Employees: 68792 (estimated)
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