47931-85-1

• 常用中文名：鲑鱼降钙素
• 常用英文名：Salmon Calcitonin Acetate
• CAS号：47931-85-1
• 分子式：C₁₄₅H₂₄₀N₄₄O₄₈S₂
• 分子量：3431.853
• 相关类别： 生物化工 氨基酸及其衍生物 其他保护氨基酸
• 发布时间：2018-02-03 08:00:00
• 更新时间：2024-01-01 20:16:01
• Calcitonin salmon 是一种钙调节激素,是阿米林和卡西宁受体 (amylin, calcitonin receptor) 的双激动剂,能够刺激骨的生成并能抑制骨吸收。

名称

• 中文名: 鲑鱼降钙素
• 英文名: calcitonin
• 中文别名: 醋酸鲑降钙素; 醋酸鲑鱼降钙素; 鲑降钙素; 鲑降钙素; 降钙素.鲑鱼
• 英文别名: MFCD00133859; tz-ct; Calcitoran; Calcitoninsalmon; Thyrocalcitonin; calcimar; Calcitonin salmon; Calcitonin; SALMON; Salmon Calcium; Salmon Calcitonin Acetate; EINECS 256-342-8; Salmotonin; Salcitonin; Salcatonin; cibacalcin; Salmon Calcitonin; Calcitonin (salmon); CYS-SER-ASN-LEU-SER-THR-CYS-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-GLY-THR-PRO-NH2(DISULFIDE BRIDGE CYS1-CYS7)

物化性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₁₄₅H₂₄₀N₄₄O₄₈S₂
• 分子量: 3431.853
• 精确质量: 3429.713379
• PSA: 1558.81000
• LogP: -12.48
• 外观性状: 粉末
• 折射率: 1.677
• 储存条件:

  密封、在 -18 ºC下保存

• 稳定性:

  如果遵照规格使用和储存则不会分解，未有已知危险反应

• 水溶解性: 0.05 M acetic acid: 1 mg/mL, clear, colorless
• 计算化学:

  1.疏水参数计算参考值（XlogP）:-16.6

  2.氢键供体数量:52

  3.氢键受体数量:55

  4.可旋转化学键数量:99

  5.互变异构体数量:1001

  6.拓扑分子极性表面积1560

  7.重原子数量:239

  8.表面电荷:0

  9.复杂度:7970

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:34

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：粉末

  2. 密度（g/mL,25ºC）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：114.5-127.7

  5. 沸点（ºC）：未确定

  6. 沸点（ºC，3mm hg）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（ºC）：未确定

  10. 自燃点或引燃温度（ºC）： 未确定

  11. 蒸气压（kPa,20ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：可溶解的

生物活性

• 描述: Calcitonin salmon 是一种钙调节激素,是阿米林和卡西宁受体 (amylin, calcitonin receptor) 的双激动剂,能够刺激骨的生成并能抑制骨吸收。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
  多肽产品
• 靶点:

  Amylin, Calcitonin receptor[1].

• 体内研究: 口服降钙素鲑鱼治疗在干预期间剂量依赖性地减弱禁食和非禁食高血糖。在研究期结束时,口服降钙素鲑鱼治疗剂量可使糖尿病高血糖症降低~9 mM,并使HbA1c水平降低1.7％。此外,在口服葡萄糖耐量试验期间,口服降钙素鲑鱼治疗剂量依赖性地观察到葡萄糖漂移的显着降低。此外,口服降钙素鲑鱼治疗可维持高胰岛素血症并减轻高胰凝血症和总胰高血糖素样肽-1的分泌过多,主要发生在基础状态。最后,口服降钙素鲑鱼治疗在研究结束时剂量依赖性地改善胰腺β细胞功能和β细胞面积[1]。
• 动物实验: 大鼠[1]雄性ZDF大鼠用口服降钙素鲑（sCT：0.5,1.0或2mg / kg）或口服载体每天两次，从8至18周处理。 Zucker瘦大鼠作为对照组。测定空腹和非禁食血糖，糖化血红蛋白（HbA1c）和胰腺和肠促胰岛素激素水平。比较口服葡萄糖耐量试验和ip葡萄糖耐量试验，评价β细胞面积和功能[1]。
• 参考文献:

  [1]. Feigh M, et al. Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta-cell area and function in Zucker diabetic fatty rats. Br J Pharmacol. 2012 Sep;167(1):151-63.

毒性和生态

生态学数据: 对水是稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统，若无政府许可，勿将材料排入周围环境。 CHEMICAL IDENTIFICATION RTECS NUMBER : EV8000000 CHEMICAL NAME : Calcitonin (salmon) CAS REGISTRY NUMBER : 47931-85-1 LAST UPDATED : 199609 DATA ITEMS CITED : 15 MOLECULAR FORMULA : C145-H240-N44-O48-S2 MOLECULAR WEIGHT : 3432.41 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >72800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,273,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >72800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,273,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >72800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,273,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >72800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,273,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >72800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,273,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >72800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,273,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >72800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,273,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >72800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,273,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >1600 iu/kg TOXIC EFFECTS : Behavioral - food intake (animal) Gastrointestinal - nausea or vomiting REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 31,1053,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : >320 iu/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 31,1053,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >500 iu/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 31,1053,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 900 iu/kg/30D-I TOXIC EFFECTS : Behavioral - food intake (animal) Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 31,1201,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 21840 iu/kg/26W-I TOXIC EFFECTS : Behavioral - food intake (animal) Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 31,1221,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3600 iu/kg/30D-I TOXIC EFFECTS : Behavioral - food intake (animal) Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 31,1201,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 870 iu/kg/30D-I TOXIC EFFECTS : Behavioral - food intake (animal) Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 32,153,1986

安全

• 个人防护装备: Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xi
• 安全声明 (欧洲): 22-24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: EV8000000