5442-12-6

• 常用中文名：去甲斑蝥素
• 常用英文名：Norcantharidin
• CAS号：5442-12-6
• 分子式：C₈H₈O₄
• 分子量：168.147
• 相关类别： 原料药 抗肿瘤药 天然来源类抗肿瘤药
• 发布时间：2018-08-02 16:29:16
• 更新时间：2025-08-26 17:35:45

名称

• 中文名: 去甲斑蝥素
• 英文名: Norcantharidin
• 中文别名: 外式-7-氧杂双环[2,2,1]庚烷-2,3-二甲酸酐
• 英文别名: hexahydro-4,7-epoxyisobenzofuran-1,3-dione; cis-exo-hexahydro-4,7-epoxyisobenzofuran-1,3-dione; 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Anhydride; Demehylcantharidin; Wln: T C555 A ao dvovtj; Hexahydro-3,6-epoxyphthalic anhydride; demethylcantharidin; Nocantharidin; 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-; 4,10-Dioxatricyclo[5.2.1.0]decane-3,5-dione; 3,6-Endooxyphthalic anhydride,hexahydro

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 362.5±35.0 °C at 760 mmHg
• 分子式: C₈H₈O₄
• 分子量: 168.147
• 闪点: 167.0±26.0 °C
• 精确质量: 168.042252
• PSA: 52.60000
• LogP: -0.85
• 外观性状: 固体
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.550
• 储存条件: 室温

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RN8300000 CHEMICAL NAME : 7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic anhydride CAS REGISTRY NUMBER : 5442-12-6 LAST UPDATED : 199701 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C8-H8-O4 MOLECULAR WEIGHT : 168.16 WISWESSER LINE NOTATION : T C555 A AO DVOVTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#05066

安全

• 危害码 (欧洲): Xi
• WGK德国: 3
• RTECS号: RN8400000
• 海关编码: 2942000000

合成路线

5426-09-5 ~98% 5442-12-6

文献：THE CHINESE UNIVERSITY OF HONG KONG Patent: EP1749831 A1, 2007 ; Location in patent: Page/Page column 5; 6 ;

28871-63-8 ~99% 5442-12-6

文献：Salvati, Mark E.; Mitt, Toomas; Patel, Ramesh N.; Hanson, Ronald L.; Brzozowski, David; Goswami, Animesh; Chu, Linda Nga Hoong; Li, Wen-sen; Simpson, James H.; Totleben, Michael J.; He, Weixuan Patent: US2005/119228 A1, 2005 ; US 20050119228 A1

上下游产品

上游产品  2
5426-09-5 28871-63-8
下游产品  3
129-67-9 16131-62-7 16131-73-0

海关

海关编码	2942000000