57513-54-9

• 常用中文名：4-羟基-1-甲基-2-氧代-1,2-二氢喹啉-3-羧酸乙酯
• 常用英文名：1,2-DIHYDRO-4-HYDROXY-1-METHYL-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER
• CAS号：57513-54-9
• 分子式：C₁₃H₁₃NO₄
• 分子量：247.24700
• 发布时间：2018-12-18 12:21:17
• 更新时间：2024-01-08 11:57:25

名称

• 中文名: 1,2-二氢-4-羟基-1-甲基-2-氧代-3-喹啉羧酸乙酯
• 英文名: ethyl 4-hydroxy-1-methyl-2-oxoquinoline-3-carboxylate
• 英文别名: 1-methyl-4-hydroxy-2-quinolinone-3-carboxylic acid ethyl ester; ethyl 1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxylate; Ethyl 1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylate; ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate; 3-Quinolinecarboxylic acid,1,2-dihydro-4-hydroxy-1-methyl-2-oxo-,ethyl ester; ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate; ethyl 4-hydroxy-2-oxo-N-methyl-1,2-dihydroquinoline-3-carboxylate; 1,2-dihydro-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxylic acid ethyl ester; 1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester

物化性质

• 密度: 1.328g/cm3
• 沸点: 353.3ºC at 760mmHg
• 分子式: C₁₃H₁₃NO₄
• 分子量: 247.24700
• 闪点: 167.5ºC
• 精确质量: 247.08400
• PSA: 68.53000
• LogP: 1.42080
• 折射率: 1.6
• 储存条件: 2-8°C， 干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VB2009300 CHEMICAL NAME : 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-methyl-2-oxo-, ethyl ester CAS REGISTRY NUMBER : 57513-54-9 BEILSTEIN REFERENCE NO. : 0484263 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C13-H13-N-O4 MOLECULAR WEIGHT : 247.27 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IJSBDB Indian Journal of Chemistry, Section B: Organic Chemistry, Including Medicinal Chemistry. (Publications & Information Directorate, Council of Scientific and Industrial Research (CSIR), Hillside Rd., New Delhi 110 012, India) V.14B- 1976- Volume(issue)/page/year: 17,488,1979

合成路线

10328-92-4 105-53-3 ~80% 57513-54-9

文献：Ismaili, Lhassane; Refouvelet, Bernard; Robert, Jean Francois Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 3 p. 719 - 722

141-52-6 85-91-6 1663-67-8 ~72% 57513-54-9

文献：Carrer, Amandine; Brion, Jean-Daniel; Messaoudi, Samir; Alami, Mouad Advanced Synthesis and Catalysis, 2013 , vol. 355, # 10 p. 2044 - 2054

118-48-9 ~% 57513-54-9

文献：Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088

118-92-3 ~% 57513-54-9

文献：Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088

35472-56-1 ~% 57513-54-9

文献：Ukrainets, I.V.; Gorokhova, O.V.; Taran, S.G.; Bezuglyi, P.A.; Turov, A.V.; et al. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1994 , vol. 30, # 7 p. 829 - 836 Khimiya Geterotsiklicheskikh Soedinenii, 1994 , # 7 p. 958 - 966

119-68-6 ~% 57513-54-9

文献：Zikou, Lamprini; Athanasellis, Giorgos; Detsi, Anastasia; Zografos, Alexandros; Mitsos, Christos; Igglessi-Markopoulou, Olga Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 8 p. 1505 - 1508

1071-46-1 85-91-6 ~% 57513-54-9

文献：Ukrainets; Golik; Bevz; Gorokhova Chemistry of Heterocyclic Compounds, 2011 , vol. 47, # 7 p. 833 - 837

85-91-6 105-53-3 ~% 57513-54-9

文献：McHugh, Michael; Proctor, George R. Journal of Chemical Research, Miniprint, 1984 , # 8 p. 2230 - 2253