4-hydroxy-2-quinolones 199*. use of N, N'-dicyclohexylcarbodiimide in the synthesis of ethyl 4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxylates

…, NY Golik, OV Bevz, OV Gorokhova

文献索引：Ukrainets; Golik; Bevz; Gorokhova Chemistry of Heterocyclic Compounds, 2011 , vol. 47, # 7 p. 833 - 837

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被引用次数: 1

摘要

A novel method has been developed for the synthesis of 4-hydroxy-2-oxo-1, 2- dihydroquinoline-3-carboxylic acids esters based on the use of monoethyl malonate as an acylating agent in the presence of N, N'-dicyclohexylcarbodiimide and characterized by high yields and purity for the final products. Practical recommendations are given for the removal of specific admixtures.